Evidence map›Paper›PMID 33633925›Full record

ArticleClinical nephrology. Case studies2021

Membranous nephropathy in a patient with coronavirus disease 2019 (COVID-19): A case report.

Jing Miao, Mary E Fidler, Samih H Nasr, Christopher P Larsen, Ziad M Zoghby

Open access · greenAbstract readCase Reports
In one paragraph

Article in Clinical nephrology. Case studies, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. COVID-19 and Glomerular Diseases.Kidney international reports · 2023
    Review
  4. Article
  5. Review
  6. Review
  7. Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jing MiaoDivision of Nephrology and Hypertension.
Mary E FidlerDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, and.
Samih H NasrDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, and.
Christopher P LarsenArkana Laboratories, Little Rock, AR, USA.
Ziad M ZoghbyDivision of Nephrology and Hypertension.
Hypertension Institute · USArkana Laboratories · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThough respiratory, immune, and coagulation systems are major targets of coronavirus disease 2019 (COVID-19), kidney dysfunction, presenting with acute kidney injury (AKI), is also common. Most AKI cases in COVID-19 manifest as acute tubular injury (ATI) in conjunction with multiorgan failure. While initial renal pathological findings were limited to acute tubular necrosis and collapsing glomerulopathy, a recent case series reported a larger spectrum of findings. CASE REPORT: Here, we report a case of membranous nephropathy (MN) in an 81-year-old Hispanic man with underlying chronic kidney disease (CKD) stage 3 who developed ATI in the setting of COVID-19. The patient was hospitalized for hypoxic respiratory failure in the setting of AKI stage 3 with serum creatinine 7.1 mg/dL 6 days after a positive-SARS-CoV-2 screening. He was found to have nephrotic range proteinuria, glycosuria (with normal serum glucose), anemia, and hypoalbuminemia. Kidney biopsy showed ATI and early MN. Workup for primary and secondary MN was unrevealing, and serum PLA2R antibody was negative. No viral particles were observed in podocytes.

conclusionAlthough the MN could be incidental, this observation raises the question of whether SARS-CoV-2 infection can trigger or worsen an underlying MN from an exaggerated immune response associated with COVID-19.

Indexed as

acute kidney injury (AKI)coronavirus disease 2019 (COVID-19)membranous nephropathy (MN)renal pathologySRAS-CoV-2

Identifiers

PMID33633925
PMCPMC7901357
OpenAlexW3130995678

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.