ArticleCureus2021
Delusional Infestation Secondary to the Dopamine Agonist Ropirinole in a Patient With Parkinson's Disease: A Case Report With an Outline of the Biology of Psychosis.
Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- Non-visual hallucinations in Parkinson's disease: a systematic review.Journal of neurology · 2023Pooled it
- Apathy Antedating and Evolving With Dementia: A Case Report and Insights Into Apathy as a Network Dysfunction.Cureus · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Delusional infestation (DI) is a thought disorder, a delusion that one is infested with pathogens. Remarkably, these patients do not typically exhibit symptoms of anxiety or depression. The role of the dopamine D2 receptor is central to the idea of psychosis. In this article, we present a case of ropirinole-induced delusional skin infestation in a patient with Parkinson's disease, that was reversible with drug discontinuation. We seize upon this opportunity to discuss the pathology of the dopamine receptors, the glutamate N-methyl D-aspartate (NMDA) receptors and the serotonin 5-hydroxytryptamine (5HT-2A) receptors in the generation of psychosis. We outline the fundamental pharmacodynamical differences between the typical and atypical anti-psychotics that will help us understand how these agents work favorably and adversely. We also briefly review the neuroradialogy of psychosis and adumbrate on the mismatch between the meso-limbic system (motivational) and the salience network (valence) as the driver of the psychotic phenomenon.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.