Evidence map›Paper›PMID 33633875›Full record

ArticleCureus2021

Can Ferritin Levels Predict the Severity of Illness in Patients With COVID-19?

Firdevs Tugba Bozkurt, Mehmet Tercan, Gulcin Patmano, Tugba Bingol Tanrıverdi, Huseyin Avni Demir, Ugur Fahri Yurekli

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.

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  11. Ferritin/lymphocyte percentage ratio to predict the severity and mortality of COVID-19.Malawi medical journal : the journal of Medical Association of Malawi · 2023
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  20. Role of Polypeptide Inflammatory Biomarkers in the Diagnosis and Monitoring of COVID-19.International journal of peptide research and therapeutics · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Firdevs Tugba BozkurtIntensive Care Unit, University of Health Sciences, Şanlıurfa Mehmet Akif İnan Research and Training Hospital, Şanlıurfa, TUR.
Mehmet TercanDepartment of Anesthesiology and Reanimation, University of Health Sciences, Şanlıurfa Mehmet Akif İnan Research and Training Hospital, Şanlıurfa, TUR.
Gulcin PatmanoDepartment of Anesthesiology and Reanimation, University of Health Sciences, Şanlıurfa Mehmet Akif İnan Research and Training Hospital, Şanlıurfa, TUR.
Tugba Bingol TanrıverdiDepartment of Anesthesiology and Reanimation, University of Health Sciences, Şanlıurfa Mehmet Akif İnan Research and Training Hospital, Şanlıurfa, TUR.
Huseyin Avni DemirDepartment of Emergency Medicine, University of Health Sciences, Şanlıurfa Mehmet Akif İnan Research and Training Hospital, Şanlıurfa, TUR.
Ugur Fahri YurekliDepartment of Biochemistry, University of Health Sciences, Şanlıurfa Mehmet Akif İnan Research and Training Hospital, Şanlıurfa, TUR.
Şanlıurfa Mehmet Akif İnan Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study aimed to investigate whether ferritin level can predict the severity of coronavirus disease 2019 (COVID-19).

backgroundThe COVID-19 pandemic has been challenging for both patients and caregivers. Many laboratory markers have been used to better understand the causes of poor outcomes and to improve the management of COVID-19 patients.

methodsA total of 93 patients who had a positive polymerase chain reaction test result for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were included in this study. Demographic features, comorbidities, clinical and laboratory findings were obtained from the hospital database retrospectively. Patients were divided into two groups according to the disease severity as follows: mild group (n = 70) and severe group (n = 23).

resultsThe median age of the study population was 42.5 (28.3-62.8) with 69.9% male patients. Patients in the severe group were significantly older and showed a higher frequency of hypertension, diabetes mellitus, coronary artery disease, and heart failure in comparison with those in the mild group. In addition, gamma-glutamyl transferase, C-reactive protein, ferritin, interleukin-6, procalcitonin, and neutrophil to lymphocyte ratio were higher whereas albumin level was lower in patients in the severe group. Linear regression analysis demonstrated that ferritin level was the only significant predictor of disease severity (β = 0.487, t = 2.993, p = 0.004). In receiver operator characteristics curve analysis, ferritin level ≥264.5 ng/mL predicted severe COVID-19 with a sensitivity of 73.9% and specificity of 94.2%.

conclusionEarly analysis of ferritin levels in patients with COVID-19 might effectively predict the disease severity.

Indexed as

coronavirusdisease severityferritinpandemic

Identifiers

PMID33633875
PMCPMC7899245
OpenAlexW3122844952

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.