Evidence map›Paper›PMID 33633837›Full record

ReviewInterface focus2021

Carbon dioxide transport across membranes.

Marie Michenkova, Sara Taki, Matthew C Blosser, Hyea J Hwang, Thomas Kowatz, Fraser J Moss, Rossana Occhipinti, Xue Qin, Soumyo Sen, Eric Shinn and 7 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Interface focus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. CONature communications · 2022
    Pooled it
  2. Article
  3. Article
  4. Simulating Gas Permeation Through the Central Pore of AQP5.Advances in experimental medicine and biology · 2026
    Article
  5. Mechanism of COThe Journal of physiology · 2026
    Article
  6. Review
  7. Review
  8. CaBiomolecules · 2025
    Review
  9. Review
  10. Review
  11. Role of channels in thebioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Microbial Protein and Metabolite Profiles ofBiotech (Basel (Switzerland)) · 2024
    Article
  14. Neurovascular coupling and CONature communications · 2024
    Article
  15. The RHCE gene encodes the chicken blood system I.Genetics, selection, evolution : GSE · 2024
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Carbon dioxide and MAPK signalling: towards therapy for inflammation.Cell communication and signaling : CCS · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Marie MichenkovaDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0002-1546-6271
Sara TakiDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0001-6941-6942
Matthew C BlosserMork Family Department of Chemical Engineering & Materials Science, University of Southern California, Los Angeles, CA, USA.
Hyea J HwangNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Thomas KowatzDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Fraser J MossDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0002-8519-6991
Rossana OcchipintiDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Xue QinDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Soumyo SenNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Eric ShinnNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Dengke WangDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Brian S ZeiseDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Pan ZhaoDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Noah MalmstadtMork Family Department of Chemical Engineering & Materials Science, University of Southern California, Los Angeles, CA, USA.
Ardeschir Vahedi-FaridiDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Emad TajkhorshidNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, Department of Biochemistry, and Center for Biophysics and Quantitative Biology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.ORCID 0000-0001-8434-1010
Walter F BoronDepartment of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH, USA.ORCID 0000-0003-4741-7287
University School · USUniversity of Illinois Urbana-Champaign · USUniversity of Southern California · US

Funding

WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI SCHULTEN, KLAUS · 2012 to 2021
$19.0M
Multi-scale modeling of gas transport through channels in living cellsU01GM111251 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI BORON, WALTER F, SOMERSALO, ERKKI JAAKKO · 2015 to 2019
$2.9M
Role of RPTP-gamma in sensing and transducing acid-base disturbances in the renal proximal tubuleR01DK113197 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI BORON, WALTER F · 2017 to 2020
$2.0M
Acid secretion and intracellular pH regulation in proximal-tubule cellsK01DK107787 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI OCCHIPINTI, ROSSANA · 2015 to 2019
$541k
NIDDK NIH HHS K01 DK107787NIDDK NIH HHS R01 DK113197NIGMS NIH HHS P41 GM104601NIGMS NIH HHS U01 GM111251
6 · The paper itself

Abstract

Carbon dioxide (CO

Indexed as

aquaporinsgas channelsrhesus proteinssodium–bicarbonate cotransporterssolubility–diffusion

Identifiers

PMID33633837
PMCPMC7898146
OpenAlexW3129943270

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.