Evidence map›Paper›PMID 33633821›Full record

ArticleOrthopedic reviews2020

Autologous matrix-induced chondrogenesis for the treatment of osteochondral lesions of the talus: A systematic review.

Michael-Alexander Malahias, Lazaros Kostretzis, Panayiotis D Megaloikonomos, Erwin-Brian Cantiller, Dimitrios Chytas, Hajo Thermann, Christoph Becher

Open access · goldAbstract read
In one paragraph

Article in Orthopedic reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Michael-Alexander MalahiasInternational Centre for Hip, Knee and Foot Surgery, ATOS Clinic Heidelberg, Heidelberg, Germany.
Lazaros KostretzisInternational Centre for Hip, Knee and Foot Surgery, ATOS Clinic Heidelberg, Heidelberg, Germany.
Panayiotis D MegaloikonomosInternational Centre for Hip, Knee and Foot Surgery, ATOS Clinic Heidelberg, Heidelberg, Germany.
Erwin-Brian CantillerInternational Centre for Hip, Knee and Foot Surgery, ATOS Clinic Heidelberg, Heidelberg, Germany.
Dimitrios ChytasSecond Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Hajo ThermannInternational Centre for Hip, Knee and Foot Surgery, ATOS Clinic Heidelberg, Heidelberg, Germany.
Christoph BecherInternational Centre for Hip, Knee and Foot Surgery, ATOS Clinic Heidelberg, Heidelberg, Germany.
Atos (France) · FRNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was performed to determine whether Autologous Matrix-Induced Chondrogenesis (AMIC) is an effective and safe treatment option for patients with symptomatic Osteochondral defects of the Talus (OCTs) and to identify factors that influence the clinical outcome. A systematic review of the literature was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Three reviewers independently conducted the literature search using the MEDLINE/PubMed database and the Cochrane Database of Systematic Reviews. The databases were queried using the terms "autologous" AND "matrix" AND "induced" AND "chondrogenesis." Thirteen studies were eligible for review. All studies that compared the preoperative and postoperative mean values of different clinical/functional scores showed significant clinical improvement. The final postoperative mean Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score ranged from 50.9 to 74.5. The included studies indicated that age and body mass index may have a detrimental impact on the postoperative outcome. A higher re-intervention rate is expected with the open technique, mainly because of hardware removal after malleolar osteotomy. This data analysis demonstrated that both arthroscopic and open AMIC procedures are effective and safe for the treatment of OCTs. Level IV, systematic review of therapeutic studies.

Indexed as

ankleAutologous matrix-induced chondrogenesiscartilage repairosteochondral lesiontalus

Identifiers

PMID33633821
PMCPMC7883099
OpenAlexW3128195184

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.