Evidence map›Paper›PMID 33633729›Full record

ArticleFrontiers in immunology2020

Antibody Responses to Crude Gametocyte Extract Predict

Brian R Omondi, Michelle K Muthui, William I Muasya, Benedict Orindi, Ramadhan S Mwakubambanya, Teun Bousema, Chris Drakeley, Kevin Marsh, Philip Bejon, Melissa C Kapulu

Abstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Serological evidence of high exposure toMalariaWorld journal · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brian R OmondiDepartment of Biosciences, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Michelle K MuthuiDepartment of Biosciences, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
William I MuasyaDepartment of Biosciences, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Benedict OrindiDepartment of Biosciences, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Ramadhan S MwakubambanyaDepartment of Biochemistry and Molecular Biology, Egerton University, Nakuru, Kenya.
Teun BousemaDepartment of Medical Microbiology, Radboud University Medical Centre, Nijmegen, Netherlands.
Chris DrakeleyDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Kevin MarshDepartment of Biosciences, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Philip BejonDepartment of Biosciences, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Melissa C KapuluDepartment of Biosciences, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Funding

EPA EP-C-15-003Wellcome TrustWellcome Trust 092741Wellcome Trust 107499Wellcome Trust 107769
6 · The paper itself

Abstract

Background: Malaria caused by Methods: We cultured Results: Multivariable logistic regression analysis showed that IgG antibody response to crude gametocyte extract predicted both microscopic (OR=1.81 95% CI: 1.06-3.07, Conclusion: In our study, it appears that IgG responses to crude gametocyte extract are not an independent predictor of gametocyte carriage after adjusting for AMA1 responses but may predict gametocyte carriage as a proxy marker of exposure to parasites. Serological responses to AMA1 or to gametocyte extract may facilitate identification of individuals within populations who contribute to malaria transmission and support implementation of transmission-blocking interventions.

Indexed as

AdolescentAntibody FormationCarrier StateChildChild, PreschoolCross-Sectional StudiesFemaleHumansImmunoglobulin GKenyaMalaria, FalciparumMaleMicroscopyParasitemiaPlasmodium falciparumImmunoglobulin Gantibody responsegametocyte extractgametocytemiamalaria transmissionPlasmodium falciparum

Identifiers

PMID33633729
PMCPMC7902058

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.