Evidence map›Paper›PMID 33633666›Full record

ArticleFrontiers in neurology2021

Vitamin D Receptor Polymorphism and Myasthenia Gravis in Chinese Han Population.

Ji-Lan Han, Yao-Xian Yue, Xiang Gao, Yan-Chen Xie, Hong-Jun Hao, Hong-Yan Li, Xiao-Long Yu, Jie Li, Rui-Sheng Duan, Hai-Feng Li

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Vitamin D receptor and binding protein genes variants in patients with migraine.Annals of clinical and translational neurology · 2023
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Ji-Lan HanDepartment of Neurology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yao-Xian YueDepartment of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiang GaoDepartment of Allergy, Affiliated Hospital of Qingdao University, Qingdao, China.
Yan-Chen XieDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Hong-Jun HaoDepartment of Neurology, Peking University First Hospital, Beijing, China.
Hong-Yan LiDepartment of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Xiao-Long YuDepartment of Neurology, Affiliated Qingdao Central Hospital, Qingdao University, Qingdao, China.
Jie LiDepartment of Neurology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Rui-Sheng DuanDepartment of Neurology, Shandong Provincial Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Hai-Feng LiDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNQingdao University · CNShandong University · CNPeking University · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myasthenia gravis (MG) is an autoimmune disease in which antibodies bind to acetylcholine receptors (AChR) or other functional molecules in the postsynaptic membrane at the neuromuscular junction. Vitamin D (VD) has a number of pluripotent effects, which include immune-regulation and bone metabolism. The immunomodulatory actions of 1,25(OH)2D3 are mediated by its binding to a vitamin D receptor (VDR). In the study, we undertook a case-control study to explore the association between VDR gene polymorphism and the susceptibility and severity of MG patients. Four hundred and eighty MG patients and 487 healthy controls were included and gene polymorphisms of VDR were determined with improved multiplex ligation detection reaction technique and SNPscan

Indexed as

myasthenia gravispolymorphismseveritysusceptibilityvitamin D receptor

Identifiers

PMID33633666
PMCPMC7900549
OpenAlexW3126805274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.