ArticleFrontiers in neurology2020
The Role of Neuroimaging and Genetic Analysis in the Diagnosis of Children With Cerebral Palsy.
Article in Frontiers in neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Comparative Effects of Partial Body Weight-Supported and Loaded Treadmill Training on Motor Performance in Children with Cerebral Palsy: A Randomized Clinical Trial.Medicina (Kaunas, Lithuania) · 2025Trial
- The Panorama of Cerebral Palsy in Sweden Part XIV Shows Further Decrease in Prevalence and Severity in the Birth-Years 2015-2018.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Feasibility of Non-Sedate Magnetic Resonance Imaging for Children with Cerebral Palsy: Tolerance and Structural Analysis Considerations.Children (Basel, Switzerland) · 2026Article
- Neurodevelopmental disorders in children: the role of MRI in early detection and intervention planning.Frontiers in neuroscience · 2026Review
- A Specific Haplotype of theDiagnostics (Basel, Switzerland) · 2025Article
- Genetic diagnostic yield by MRI pattern in children with cerebral palsy: a population-based study.EBioMedicine · 2025Article
- Genetic investigations in cerebral palsy.Developmental medicine and child neurology · 2025Review
- Epilepsy in Cerebral Palsy: Unraveling Prevalence, Risk Factors, and Subtype Associations in a Large-Scale Population Study.Medicina (Kaunas, Lithuania) · 2024Article
- Review
- Association of epilepsy with neuroimaging patterns in children with cerebral palsy.Acta neurologica Belgica · 2024Review
- Cerebral Palsy Heterogeneity: Clinical Characteristics and Diagnostic Significance from a Large-Sample Analysis.Neuroepidemiology · 2024Article
- Prevalence, Clinical Features, Neuroimaging, and Genetic Findings in Children With Ataxic Cerebral Palsy in Europe.Neurology · 2023Article
- Association of deep phenotyping with diagnostic yield of prenatal exome sequencing for fetal brain abnormalities.Genetics in medicine : official journal of the American College of Medical Genetics · 2023Article
- [Cerebral palsy: new challenges in the era of rare diseases].Anales del sistema sanitario de Navarra · 2023Article
- An Emerging Role for Epigenetics in Cerebral Palsy.Journal of personalized medicine · 2021Review
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral magnetic resonance imaging (MRI) is considered an important tool in the assessment of a child with cerebral palsy (CP), as it is abnormal in more than 80% of children with CP, disclosing the pathogenic pattern responsible for the neurological condition. MRI, therefore, is recommended as the first diagnostic step after medical history taking and neurological examination. With the advances in genetic diagnostics, the genetic contribution to CP is increasingly discussed, and the question arises about the role of genetic testing in the diagnosis of cerebral palsy. The paper gives an overview on genetic findings reported in CP, which are discussed with respect to the underlying brain pathology according to neuroimaging findings. Surveillance of Cerebral Palsy in Europe (SCPE) classifies neuroimaging findings in CP into five categories, which help to stratify decisions concerning genetic testing. Predominant white and gray matter injuries are by far predominant (accounting for around 50 and 20% of the findings). They are considered to be acquired. Here, predisposing genetic factors may play a role to increase vulnerability (and should especially be considered, when family history is positive and/or causative external factors are missing). In maldevelopments and normal findings (around 11% each), monogenic causes are more likely, and thus, genetic testing is clearly recommended. In the miscellaneous category, the precise nature of the MRI finding has to be considered as it could indicate a genetic origin.
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