Evidence map›Paper›PMID 33633535›Full record

ArticleFrontiers in neuroscience2021

Survival Predictors of Heart Rate Variability After Myocardial Infarction With and Without Low Left Ventricular Ejection Fraction.

Junichiro Hayano, Norihiro Ueda, Masaya Kisohara, Emi Yuda, Robert M Carney, James A Blumenthal

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  11. Heart rate variability: reference values and role for clinical profile and mortality in individuals with heart failure.Clinical research in cardiology : official journal of the German Cardiac Society · 2024
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  17. Prognostic significance of the Holter-derived T-wave variability in patients with ventricular tachyarrhythmias complicating acute coronary syndrome-TWIST study.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Junichiro HayanoDepartment of Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Norihiro UedaDepartment of Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Masaya KisoharaDepartment of Medical Education, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Emi YudaTohoku University Graduate School of Engineering, Sendai, Japan.
Robert M CarneyDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, United States.
James A BlumenthalDepartment of Psychiatry, Duke University Medical Center, Durham, NC, United States.

Funding

Exercise, Depression, and Cardiac RiskR01HL080664 · NHLBI · DUKE UNIVERSITY · PI BLUMENTHAL, JAMES A · 2006 to 2010
$3.7M
Stress Management and Biomarkers of Risk in Cardiac RehabilitationR01HL093374 · NHLBI · DUKE UNIVERSITY · PI BLUMENTHAL, JAMES A · 2009 to 2014
$3.7M
Depression &Mortality Following Myocardial InfarctionR01HL058946 · NHLBI · WASHINGTON UNIVERSITY · PI CARNEY, ROBERT M · 2003 to 2005
$920k
DEPRESSION AND MORTALITY FOLLOWING MYOCARDIAL INFARCTIONU01HL058946 · NHLBI · WASHINGTON UNIVERSITY · PI CARNEY, ROBERT M · 1997 to 2000
$315k
NHLBI NIH HHS R01 HL058946NHLBI NIH HHS R01 HL080664NHLBI NIH HHS R01 HL093374NHLBI NIH HHS U01 HL058946
6 · The paper itself

Abstract

backgroundHeart rate variability (HRV) and heart rate (HR) dynamics are used to predict the survival probability of patients after acute myocardial infarction (AMI), but the association has been established in patients with mixed levels of left ventricular ejection fraction (LVEF).

objectiveWe investigated whether the survival predictors of HRV and HR dynamics depend on LVEF after AMI.

methodsWe studied 687 post-AMI patients including 147 with LVEF ≤35% and 540 with LVEF >35%, of which 23 (16%) and 22 (4%) died during the 25 month follow-up period, respectively. None had an implanted cardioverter-defibrillator. From baseline 24 h ECG, the standard deviation (SDNN), root mean square of successive difference (rMSSD), percentage of successive difference >50 ms (pNN50) of normal-to-normal R-R interval, ultra-low (ULF), very-low (VLF), low (LF), and high (HF) frequency power, deceleration capacity (DC), short-term scaling exponent (α

resultsThe predictors were categorized into three clusters; DC, SDNN, α

conclusionThe mortality risk in post-AMI patients with low LVEF is predicted by indices reflecting decreased HRV or HR responsiveness and cardiac parasympathetic dysfunction, whereas in patients without low LVEF, the risk is predicted by a combination of indices that reflect decreased HRV or HR responsiveness and indicator that reflects abrupt large HR changes suggesting sympathetic involvement.

Indexed as

heart rate dynamicsheart rate variabilityleft ventricular ejection fractionmortalitymyocardial Infarctionredundancyrisk stratificationsurvival

Identifiers

PMID33633535
PMCPMC7901937

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.