ArticleNature medicine2021
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity.
2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph
Article in Nature medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 179 papers, 8 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 8 pooled it
20.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Uppsala Intensive Care Study of Mechanisms for Organ Dysfunction in Covid-19
Host-pathogen Interactions, Immune Response, and Clinical Prognosis at COVID-19 - the CoVUm Trial
Who cites it
179 citing papers in PubMed, 8 syntheses or guidelines pooled it, 290 citations in OpenAlex.
- Exploring the Relationship Between Antipsychotic Drug Target Genes and Epilepsy: Evidence From Food and Drug Administration Adverse Event Reporting System Database and Mendelian Randomization.Brain and behavior · 2025Pooled it
- Canadian COVID-19 host genetics cohort replicates known severity associations.PLoS genetics · 2024Pooled it
- Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks.PLoS genetics · 2023Pooled it
- Comprehensive proteomics and meta-analysis of COVID-19 host response.Nature communications · 2023Pooled it
- Pooled it
- Mendelian randomization and genetic colocalization infer the effects of the multi-tissue proteome on 211 complex disease-related phenotypes.Genome medicine · 2022Pooled it
- Identifying factors contributing to increased susceptibility to COVID-19 risk: a systematic review of Mendelian randomization studies.International journal of epidemiology · 2022Pooled it
- Gene Expression Meta-Analysis Reveals Interferon-Induced Genes Associated With SARS Infection in Lungs.Frontiers in immunologyPooled it
- Proteome-wide Mendelian randomization identifies APOM and TNXB as actionable mediators of steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2026Article
- Disentangling Shared and Differential Genetic Architectures Between COVID-19 and Other Respiratory Disorders-A Genome-Wide Multi-Omics Framework.International journal of molecular sciences · 2026Article
- Integrating single-cell sQTL mapping with deep-learning splicing prediction identifies causal variants under influenza infection.Genome biology · 2026Article
- Temporal Dynamics of Innate Immune Activation and Viral Interference During Sequential Co-Infection with Influenza A Virus and SARS-CoV-2: Molecular Mechanisms, Clinical Evidence, and Therapeutic Implications.International journal of molecular sciences · 2026Review
- SARS-CoV-2 5'-UTR stem-loops activate the antiviral protein oligoadenylate synthetase 1 (OAS1).The Journal of biological chemistry · 2026Article
- Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania.Science (New York, N.Y.) · 2026Article
- SARS-CoV-2 5'-UTR stem-loops activate the antiviral protein oligoadenylate synthetase 1 (OAS1).bioRxiv : the preprint server for biology · 2026Article
- Unmasking FCGR2B as a high-grade serous ovarian cancer specific marker of immune suppression and tumor progression through multi-omics mining.Translational oncology · 2026Article
- Widespread gene-environment interactions shape the immune response to SARS-CoV-2 infection in hospitalized COVID-19 patients.Nature communications · 2026Article
- Causal inference of glucocorticoid signaling in non-small cell lung cancer: integrating Mendelian randomization, single-cell transcriptomics, and imaging data.NPJ precision oncology · 2026Article
- The Rayleigh Quotient and Contrastive Principal Component Analysis II.bioRxiv : the preprint server for biology · 2026Article
- The FunctionalInternational journal of molecular sciences · 2026Article
119 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
41 authors at 10 institutions in 6 countries.
Sirui Zhou *Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Guillaume Butler-Laporte *Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0001-5388-0396
Tomoko Nakanishi *Lady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0001-9510-5646
David R MorrisonLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0001-8380-3615
Jonathan AfilaloLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Marc AfilaloLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Laetitia LaurentLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Maik PietznerMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Nicola KerrisonMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.
Kaiqiong ZhaoLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Elsa Brunet-RatnasinghamResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0002-3613-1315
Danielle HenryLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Nofar KimchiLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Zaman AfrasiabiLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0003-4395-5168
Nardin RezkLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0001-5358-7704
Meriem BouabLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Louis PetitjeanLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0002-9223-5100
Charlotte GuzmanLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0002-2979-4436
Xiaoqing XueLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Chris TseliosLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Branka VulesevicLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Olumide AdeleyeLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Tala AbdullahLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Noor AlmamloukLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Yiheng ChenLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Michaël ChasséResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Madeleine DurandResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Clare PatersonSomaLogic, Inc., Boulder, CO, USA.
Johan NormarkMolecular Infection Medicine Sweden (MIMS) and Wallenberg Center for Molecular Medicine, Department of Clinical Microbiology, Section of Infection and Immunology, Umeå University, Umeå, Sweden.
Robert FrithiofAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-2278-7951
Miklós LipcseyAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Michael HultströmAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0003-4675-1099
Celia M T GreenwoodLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0002-2427-5696
Hugo ZebergDepartment of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.ORCID http://orcid.org/0000-0002-5017-7344
Elin ThysellDepartment of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.
Michael PollakLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Vincent MooserDepartment of Human Genetics, McGill University, Montréal, Quebec, Canada.
Vincenzo ForgettaLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada.
Daniel E KaufmannResearch Centre of the Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.ORCID http://orcid.org/0000-0003-4467-136X
J Brent RichardsLady Davis Institute, Jewish General Hospital, McGill University, Montréal, Quebec, Canada. brent.richards@mcgill.ca.ORCID http://orcid.org/0000-0002-3746-9086
Jewish General Hospital · CACentre Hospitalier de l’Université de Montréal · CAUniversity of Cambridge · GBUppsala University · SEUmeå University · SEJapan Society for the Promotion of Science · JPKarolinska Institutet · SEKing's College London · GBMcGill University · CASomaLogic (United States) · US
Funding
Medical Research Council MC_UU_00006/1
Abstract
To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly scanning hundreds of circulating proteins while reducing bias due to reverse causation and confounding. In up to 14,134 cases and 1.2 million controls, we found that an s.d. increase in OAS1 levels was associated with reduced COVID-19 death or ventilation (odds ratio (OR) = 0.54, P = 7 × 10
Indexed as
Genetic Predisposition to DiseaseSARS-CoV-22',5'-Oligoadenylate SynthetaseAgedAged, 80 and overAnimalsCase-Control StudiesCOVID-19FemaleHumansInterleukin-10 Receptor beta SubunitMaleMendelian Randomization AnalysisMiddle AgedNeanderthalsProtein Isoforms2',5'-Oligoadenylate SynthetaseIL10RB protein, humanInterleukin-10 Receptor beta SubunitOAS1 protein, humanProtein Isoforms
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT04316884ClinicalTrials.gov
NCT04368013ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.