ArticleNature structural & molecular biology2021
Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
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Article in Nature structural & molecular biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80citing papers in PubMed
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80 citing papers in PubMed, 121 citations in OpenAlex.
- Atomic, structural and molecular insights into GPCR ligand binding and signalling.Nature reviews. Molecular cell biology · 2026Review
- Ligand-dependent G protein dynamics underlying opioid efficacy.Nature structural & molecular biology · 2026Article
- Docking of virtual libraries identifies small-molecule agonists of neurotensin receptors with analgesic activity.Nature communications · 2026Article
- Tool antibody fragments reveal multiple conformations of the rhodopsin-Gi signaling complex.Biophysical journal · 2026Article
- Structural and dynamic studies uncover a distinct allosteric modulatory site at the µ-opioid receptor.Nature communications · 2026Article
- Structural insight into ligand binding and activation of the orphan GPCR Mas1.The EMBO journal · 2026Article
- Determinants of drug efficacy and the dynamics of G protein activation.Nature structural & molecular biology · 2026Article
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- Molecular Mechanisms Governing Peptide Nanodisc Assembly and Stability.bioRxiv : the preprint server for biology · 2026Article
- Mapping the Ligand-dependent Remodeling of the Conformational Entropy Landscape in Neurotensin Receptor 1 by NMR-guided Molecular Simulations.bioRxiv : the preprint server for biology · 2026Article
- Lipid Dependence of CYP3A4 Activity in Nanodiscs.Biology · 2026Article
- The Nanodisc System for Investigating Protein-Lipid Interactions.Methods in molecular biology (Clifton, N.J.) · 2026Review
- Deciphering a mechanistic basis for the pathological effect of the GNAO1 E246K variant in neurodevelopmental disorder.BBA advances · 2026Article
- Biological Breakthroughs and Drug Discovery Revolution via Cryo-Electron Microscopy of Membrane Proteins.Membranes · 2025Review
- Structural insights into antagonist recognition by the vasopressin V2 receptor.Nature communications · 2025Article
- Structural and dynamic studies uncover a distinct allosteric modulatory site at the μ-opioid receptor.bioRxiv : the preprint server for biology · 2025Article
- The influence of lipids and biological membranes on the conformational equilibria of GPCRs: Insights from NMR spectroscopy.Current opinion in structural biology · 2025Review
- Dual-Selective Terahertz-Nanodisc Metasurfaces for Exploring Neurotransmitter Dynamics beyond Spectral Limitations.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Dimerization propensity of the βProceedings of the National Academy of Sciences of the United States of America · 2025Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 4 institutions in 3 countries.
Meng Zhang *Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4497-3253
Miao Gui *Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9113-8029
Zi-Fu WangDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Christoph GorgullaDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
James J YuDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Hao WuDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Zhen-Yu J SunDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Christoph KlenkDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0001-5199-7144
Lisa MerklingerDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.
Lena MorsteinDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.
Franz HagnBavarian NMR Center at the Department of Chemistry, Technical University of Munich, Garching, Germany.ORCID http://orcid.org/0000-0002-1315-459X
Andreas PlückthunDepartment of Biochemistry, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-4191-5306
Alan BrownDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Alan_Brown@hms.harvard.edu.ORCID http://orcid.org/0000-0002-0021-0476
Mahmoud L NasrDepartment of Medicine, Division of Renal Medicine, Division of Engineering in Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mnasr@bwh.harvard.edu.
Gerhard WagnerDepartment of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Gerhard_Wagner@hms.harvard.edu.ORCID http://orcid.org/0000-0002-2063-4401
Harvard University · USUniversity of Zurich · CHBrigham and Women's Hospital · USHelmholtz Zentrum München · DE
Funding
OverallP41EB002026 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFIN, ROBERT GUY · 2003 to 2018
$17.9MSTRUCTURE BASIS OF IMMUNE-CELL SURFACE RECEPTOR FUNCTIONR01AI037581 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WAGNER, GERHARD · 1996 to 2021
$6.7MTR&D 4 -- Advanced Magic Angle Spinning NMR methodsP41GM132079 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFIN, ROBERT GUY · 2019 to 2021
$3.6MRoles of Eukaryotic Translation Initiation Factors in Gene ExpressionR01CA200913 · NCI · HARVARD MEDICAL SCHOOL · PI WAGNER, GERHARD · 2016 to 2020
$2.3MMechanoregulation of Ciliary MotilityR01GM141109 · NIGMS · HARVARD MEDICAL SCHOOL · PI BROWN, ALAN · 2021 to 2025
$2.1MNext Generation Solution NMR Techniques for GPCR Structure, Dynamics and FunctionR01GM129026 · NIGMS · HARVARD MEDICAL SCHOOL · PI WAGNER, GERHARD · 2018 to 2021
$2.0MDNA-corralled nanodiscs for study of large membrane proteins and their complexesR01GM131401 · NIGMS · HARVARD UNIVERSITY · PI SHIH, WILLIAM M · 2018 to 2021
$1.7MNew RF Electronics Console and Probes for 900 Mhz NMR SpectrometerS10OD023513 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GRIFFIN, ROBERT GUY · 2018 to 2018
$1.0M600 MHz NMR Spectrometer ConsoleS10OD028526 · OD · HARVARD MEDICAL SCHOOL · PI WAGNER, GERHARD · 2020 to 2020
$649k800 MHz Triple Resonance Observe (TXO) Detection CryoProbeS10RR026417 · NCRR · HARVARD MEDICAL SCHOOL · PI WAGNER, GERHARD · 2010 to 2010
$359kNCI NIH HHS R01 CA200913NCRR NIH HHS S10 RR026417NIAID NIH HHS R01 AI037581NIBIB NIH HHS P41 EB002026NIGMS NIH HHS P41 GM132079NIGMS NIH HHS R01 GM129026NIGMS NIH HHS R01 GM131401NIGMS NIH HHS R01 GM141109NIH HHS S10 OD023513NIH HHS S10 OD028526
Abstract
G-protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane proteins and the targets of over 30% of currently marketed pharmaceuticals. Although several structures have been solved for GPCR-G protein complexes, few are in a lipid membrane environment. Here, we report cryo-EM structures of complexes of neurotensin, neurotensin receptor 1 and Gα
Indexed as
Cryoelectron MicroscopyLipid BilayersAllosteric RegulationGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsGuanosine DiphosphateHeterotrimeric GTP-Binding ProteinsHumansMicellesModels, MolecularNanostructuresNeurotensinProtein ConformationReceptors, NeurotensinSignal TransductionGTP-Binding Protein alpha Subunits, Gi-GoGTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsGuanosine DiphosphateHeterotrimeric GTP-Binding ProteinsLipid BilayersMicellesNeurotensinneurotensin type 1 receptorReceptors, Neurotensin
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