Evidence map›Paper›PMID 33633342›Full record

SynthesisInternational journal of obesity (2005)2021

Admixture/fine-mapping in Brazilians reveals a West African associated potential regulatory variant (rs114066381) with a strong female-specific effect on body mass and fat mass indexes.

Marilia O Scliar, Hanaisa P Sant'Anna, Meddly L Santolalla, Thiago P Leal, Nathalia M Araújo, Isabela Alvim, Victor Borda, Wagner C S Magalhães, Mateus H Gouveia, Ricardo Lyra and 33 more

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PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of obesity (2005), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors at 18 institutions in 7 countries.

Marilia O Scliar *Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Hanaisa P Sant'Anna *Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Meddly L Santolalla *Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Thiago P LealDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Nathalia M AraújoDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Isabela AlvimDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0001-9452-9244
Victor BordaDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Wagner C S MagalhãesDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Mateus H GouveiaDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Ricardo LyraDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0002-8334-7880
Moara MachadoDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Lucas MichelinDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Maíra R RodriguesDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0003-3193-9558
Gilderlanio S AraújoPrograma de Pós-graduação em Genética e Biologia Molecular, Laboratório de Genética Humana e Médica, Instituto de Ciências Biológicas, Universidade Federal do Pará-Campus Guamá, Belém, PA, Brazil.ORCID http://orcid.org/0000-0001-9199-9419
Fernanda S G KehdyDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Camila ZoliniDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0002-9394-8807
Sérgio V PeixotoInstituto de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0001-9431-2280
Marcelo R LuizonDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.ORCID http://orcid.org/0000-0002-8331-3525
Francisco LoboDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Michel S NaslavskyHuman Genome and Stem Cell Research Center, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, Brazil.
Guilherme L YamamotoHuman Genome and Stem Cell Research Center, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, Brazil.
Yeda A O DuarteDepartment of Epidemiology, Public Health School, Universidade de São Paulo, São Paulo, SP, Brazil.
Matthew E B HansenDepartments of Biology and Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Shane A NorrisSAMRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Robert H GilmanEmerge, Emerging Diseases and Climate Change Research Unit, School of Public Health and Administration, Universidad Peruana Cayetano Heredia, Lima, Peru.
Heinner GuioInstituto Nacional de Salud, Lima, Peru.
Ann W HsingStanford Cancer Institute, Stanford University, Stanford, CA, USA.
Sam M MbulaiteyeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8273-9831
James MensahUniversity of Ghana Medical School, Accra, Ghana.ORCID http://orcid.org/0000-0003-4133-1722
Julie DutilCancer Biology Division, Ponce Research Institute, Ponce Health Sciences University, Ponce, Puerto Rico.
Meredith YeagerCancer Genomics Research Laboratory, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Edward YeboahUniversity of Ghana Medical School, Accra, Ghana.
Sarah A TishkoffDepartments of Biology and Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Ananyo ChoudhurySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Michele RamsaySydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-4156-4801
Maria Rita Passos-BuenoHuman Genome and Stem Cell Research Center, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, Brazil.
Mayana ZatzHuman Genome and Stem Cell Research Center, Instituto de Biociências, Universidade de São Paulo, São Paulo, SP, Brazil.
Timothy D O ConnorInstitute of Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Alexandre C PereiraInstituto do Coração, Universidade de São Paulo, São Paulo, SP, Brazil.
Mauricio L BarretoInstituto de Saúde Coletiva, Universidade Federal da Bahia, Salvador, BA, Brazil.
Maria Fernanda Lima-CostaInstituto de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.
Bernardo L HortaPrograma de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil.ORCID http://orcid.org/0000-0001-9843-412X
Eduardo Tarazona-SantosDepartamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. edutars@icb.ufmg.br.
Universidade Federal de Minas Gerais · BRUniversidade de São Paulo · BRUniversity of Ghana · GHUniversity of Pennsylvania · USFundação Oswaldo Cruz · BRInstituto Nacional de Salud · PEJohns Hopkins University · USLeidos (United States) · USNational Health Laboratory Service · ZANational Institutes of Health · USPonce Health Sciences University · PRSouth African Medical Research Council · ZAStanford University · USUniversidade Federal da Bahia · BRUniversidade Federal de Pelotas · BRUniversidade Federal do Pará · BRUniversity of Maryland, Baltimore · USUniversity of the Witwatersrand · ZA

Funding

Epidemiology and Natural History of Cancer-Associated VirusesZIACP010176 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI MBULAITEYE, SAM M · 2009 to 2025
$33.7M
Rapid Evolution of Genomic Architecture and Multi-omics TraitsR35HG010692 · NHGRI · UNIVERSITY OF MARYLAND BALTIMORE · PI O'CONNOR, TIMOTHY DAVID · 2019 to 2023
$2.3M
NHGRI NIH HHS R35 HG010692
6 · The paper itself

Abstract

BACKGROUND/

objectivesAdmixed populations are a resource to study the global genetic architecture of complex phenotypes, which is critical, considering that non-European populations are severely underrepresented in genomic studies. Here, we study the genetic architecture of BMI in children, young adults, and elderly individuals from the admixed population of Brazil. SUBJECTS/

methodsLeveraging admixture in Brazilians, whose chromosomes are mosaics of fragments of Native American, European, and African origins, we used genome-wide data to perform admixture mapping/fine-mapping of body mass index (BMI) in three Brazilian population-based cohorts from Northeast (Salvador), Southeast (Bambuí), and South (Pelotas).

resultsWe found significant associations with African-associated alleles in children from Salvador (PALD1 and ZMIZ1 genes), and in young adults from Pelotas (NOD2 and MTUS2 genes). More importantly, in Pelotas, rs114066381, mapped in a potential regulatory region, is significantly associated only in females (p = 2.76e-06). This variant is rare in Europeans but with frequencies of ~3% in West Africa and has a strong female-specific effect (95% CI: 2.32-5.65 kg/m

conclusionsWe identified six candidate SNPs associated with BMI. rs114066381 stands out for its high effect that was replicated and its high frequency in women with morbid obesity. We demonstrate how admixed populations are a source of new relevant phenotype-associated genetic variants.

Indexed as

Body Mass IndexGenetics, PopulationPolymorphism, Single NucleotideAgedAged, 80 and overAllelesBrazilChildChild, PreschoolChromosome MappingFemaleHumansMaleMiddle AgedPhenotypeRegulatory Sequences, Nucleic Acid

Identifiers

PMID33633342
PMCPMC9952852
OpenAlexW3132762845

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.