Evidence map›Paper›PMID 33633304›Full record

ArticleScientific reports2021

A glycoside analog of mammalian oligomannose formulated with a TLR4-stimulating adjuvant elicits HIV-1 cross-reactive antibodies.

Jean-François Bruxelle, Tess Kirilenko, Nino Trattnig, Yiqiu Yang, Matteo Cattin, Paul Kosma, Ralph Pantophlet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Jean-François BruxelleFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Tess KirilenkoFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada.
Nino TrattnigDepartment of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria.
Yiqiu YangDepartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Matteo CattinDepartment of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria.
Paul KosmaDepartment of Chemistry, University of Natural Resources and Life Sciences, Vienna, Austria.
Ralph PantophletFaculty of Health Sciences, Simon Fraser University, Burnaby, BC, Canada. rpantophlet@sfu.ca.
Simon Fraser University · CABOKU University · AT

Funding

Synthetic bacterial analogs of mammalian oligomannose for eliciting neutralizing antibodies to the high-mannose patch on HIV EnvR01AI134299 · NIAID · SIMON FRASER UNIVERSITY · PI PANTOPHLET, RALPH ALPHONSO · 2017 to 2025
$3.8M
NIAID NIH HHS R01 AI134299
6 · The paper itself

Abstract

The occurrence of oligomannose-specific broadly neutralizing antibodies (bnAbs) has spurred efforts to develop immunogens that can elicit similar antibodies. Here, we report on the antigenicity and immunogenicity of a CRM

Indexed as

Cross ReactionsAnimalsHIV-1HIV AntibodiesMannoseMiceMice, TransgenicToll-Like Receptor 4HIV AntibodiesMannoseToll-Like Receptor 4

Identifiers

PMID33633304
PMCPMC7907241
OpenAlexW3123278129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.