Observational studyScientific reports2021
Post-traumatic seizures and antiepileptic therapy as predictors of the functional outcome in patients with traumatic brain injury.
Observational study in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Early post-traumatic seizure as severity predictor of traumatic brain injury: A meta-analysis and systematic review.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2026Pooled it
- Clinical risk factors for post-traumatic seizures: a systematic review and meta-analysis.Journal of neurology · 2026Pooled it
- An Interplay Between Post-Traumatic Epilepsy and Associated Cognitive Decline: A Systematic Review.Frontiers in neurology · 2022Pooled it
- Evaluation of long-term quality of life in traumatic brain injury patients early treated with biperiden - a randomized controlled trial.BMC neurology · 2026Trial
- Seizure Rates in Mild and Moderate Traumatic Brain Injury With Intracranial Hemorrhage: A Signal for Prospective Investigation of Seizure Prophylaxis in Moderate TBI.World journal of surgery · 2026Article
- Review
- Prophylactic anti-seizure medication for post-traumatic seizures in Chinese PICUs: current practices and knowledge gaps.BMC neurology · 2026Article
- Neurostimulant Use and Cognitive Outcomes in Patients with Acute, Severe Traumatic Brain Injury.Neurocritical care · 2026Article
- Rehabilitation After Severe Traumatic Brain Injury with Acute Symptomatic Seizure: Neurofeedback and Motor Therapy in a 6-Month Follow-Up Case Study.Neurology international · 2026Article
- Chronic behavioral and seizure outcomes following experimental traumatic brain injury and comorbid Klebsiella pneumoniae lung infection in mice.Epilepsia · 2025Article
- Antiseizure Medication Prescription Patterns for Treatment of Post-Traumatic Epilepsy.Neurology. Clinical practice · 2025Article
- Predictive value of peripheral blood inflammatory markers for epilepsy occurrence in traumatic brain injury patients.Acta epileptologica · 2025Article
- Development and validation of a model to predict cognitive impairment in traumatic brain injury patients: a prospective observational study.EClinicalMedicine · 2025Article
- Post-traumatic epilepsy: bridging pathogenesis, diagnosis, and pharmacotherapeutic strategies.Frontiers in pharmacology · 2025Review
- Insights into epileptogenesis from post-traumatic epilepsy.Nature reviews. Neurology · 2024Review
- Post-traumatic seizures and factors associated among adult patients with depressed skull fractures at Mulago National Referral hospital; cross-sectional study.Epilepsy & behavior : E&B · 2024Article
- Posttraumatic Epilepsy and Dementia Risk.JAMA neurology · 2024Article
- Article
- The Australian Traumatic Brain Injury Initiative: Systematic Review of Clinical Factors Associated with Outcomes in People with Moderate-Severe Traumatic Brain Injury.Neurotrauma reports · 2024Review
- Research Progress on the Immune-Inflammatory Mechanisms of Posttraumatic Epilepsy.Cellular and molecular neurobiology · 2023Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-traumatic seizures (PTS) are a common and debilitating complication of traumatic brain injury (TBI) and could have a harmful impact on the progress of patient rehabilitation. To assess the effect of PTS and relative therapy on outcome in the initial phase after TBI, during the rehabilitation process when neuroplasticity is at its highest, we retrospectively examined the clinical data of 341 adult patients undergoing rehabilitation for at least 6 months post-TBI in our neurorehabilitation unit between 2008 and 2019. We correlated through logistic regression the occurrence of seizures and use of anti-seizure medication (ASM) with neurological and functional outcomes, respectively assessed with the Glasgow Coma Scale (GCS) and the Functional Independence Measure (FIM). PTS were documented in 19.4% of patients: early PTS (EPTS) in 7.0%; late PTS (LPTS) in 9.4%; both types in 3.0%. Patients who developed EPTS had an increased risk of developing LPTS (OR = 3.90, CI 95% 1.58-9.63, p = 0.003). Patients with LPTS had a significantly higher risk of worse neurological (p < 0.0001) and rehabilitation (p < 0.05) outcome. Overall, 38.7% of patients underwent therapy with ASM; prophylactic therapy was prescribed in 24.0% of patients, of whom 14.6% subsequently developed seizures. Mortality was associated with a lower FIM and GCS score on admission but not significantly with PTS. The use of ASM was associated with a worse rehabilitation outcome, independently of the onset of epilepsy during treatment. LPTS appear to exert a negative impact on rehabilitation outcome and their occurrence is not reduced by prophylactic therapy, whereas EPTS do not influence outcome. Our findings caution against the generic use of prophylactic therapy to prevent post-traumatic epilepsy in patients with TBI.
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