ArticleScientific reports2021
Association of changes of retinal vessels diameter with ocular blood flow in eyes with diabetic retinopathy.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 54 citations in OpenAlex.
- Evaluation of the Effect of Garlic Tablet as a Complementary Treatment for Patients with Diabetic Retinopathy.Journal of diabetes research · 2022Trial
- Association of the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) Score with Diabetic Retinopathy Severity: A Case-Control Comparison with Non-Diabetic Ophthalmology Patients.Journal of clinical medicine · 2026Article
- Retinal blood flow increases with diabetic retinopathy severity in type 2 diabetes: a cross-sectional study using laser doppler velocimetry.Scientific reports · 2026Article
- Diabetes May Modulate the Association Between Age and Optical Coherence Tomography Angiography Parameters: A Serial, Cross-Sectional Study.Journal of personalized medicine · 2026Article
- Selected Aspects of Optical Coherence Tomography and Adaptive Optics in Patients with Increased Body Mass Index.Biomedicines · 2026Article
- RETINAL PHOTORECEPTORS AND ARTERIOLES ALTERATIONS DETECTED USING ADAPTIVE OPTICS SCANNING LASER OPHTHALMOSCOPY IN DIABETES AND DIABETIC RETINOPATHY.Retina (Philadelphia, Pa.) · 2026Article
- Laser Speckle Flowgraphy (LSFG) in Age-Related Macular Degeneration and Diabetic Retinopathy: A Systematic Review of Recent Literature.Journal of clinical medicine · 2025Review
- Retinal Microvascular Resistance Estimated From Waveform Analysis Is Significantly Higher in Diabetic Retinopathy.Translational vision science & technology · 2025Article
- Visual stimulus-evoked transient blood flow and blood vessel diameter changes in the healthy human retina measured with a combined OCT+ERG system.Biomedical optics express · 2025Article
- Article
- Investigation of Ocular Blood Flow in Males with Metabolic Syndrome.Diagnostics (Basel, Switzerland) · 2025Article
- Assessment of Microvascular Disturbances in Children with Type 1 Diabetes-A Pilot Study.Biosensors · 2025Article
- Multimodal Imaging of Diabetic Retinopathy: Insights from Optical Coherence Tomography Angiography and Adaptive Optics.Diagnostics (Basel, Switzerland) · 2025Article
- Combined optical coherence tomography and electroretinography system for imaging neurovascular coupling in the human retina.Neurophotonics · 2025Article
- Characterizing Vascular Wall and Lumen Caliber in Eyes with Diabetic Retinopathy Based on Adaptive Optics Scanning Laser Ophthalmoscopy.Diagnostics (Basel, Switzerland) · 2024Article
- Hypertension Likely Drives Arteriolar Wall Thickening in Preclinical Diabetic Retinopathy While Diabetes Drives Wall Thickness in Clinical Retinopathy.Translational vision science & technology · 2024Article
- The Role and Therapeutic Potential of Melatonin in Degenerative Fundus Diseases: Diabetes Retinopathy and Age-Related Macular Degeneration.Drug design, development and therapy · 2024Review
- Clinical Application of Adaptive Optics Imaging in Diagnosis, Management, and Monitoring of Ophthalmological Diseases: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- Adaptive vessel tracing and segmentation in OCT enables the robust detection of wall-to-lumen ratio abnormalities in 5xFAD mice.Biomedical optics express · 2023Article
- Retinal Arteriolar Wall Remodeling in Diabetes Captured With AOSLO.Translational vision science & technology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated morphological changes of retinal arteries to determine their association with the blood flow and systemic variables in type 2 diabetes patients. The patients included 47 non-diabetic retinopathy eyes, 36 mild or moderate nonproliferative diabetic retinopathy (M-NPDR) eyes, 22 severe NPDR (S-NPDR) eyes, 32 PDR eyes, and 24 normal eyes as controls. The mean wall to lumen ratio (WLR) measured by adaptive optics camera was significantly higher in the PDR groups than in all of the other groups (all P < 0.001). However, the external diameter of the retinal vessels was not significantly different among the groups. The mean blur rate (MBR)-vessel determined by laser speckle flowgraphy was significantly lower in the PDR group than in the other groups (P < 0.001). The WLR was correlated with MBR-vessel (r = - 0.337, P < 0.001), duration of disease (r = 0.191, P = 0.042), stage of DM (r = 0.643, P < 0.001), systolic blood pressure (r = 0.166, P < 0.037), and presence of systemic hypertension (r = 0.443, P < 0.001). Multiple regression analysis demonstrated that MBR-vessel (β = - 0.389, P < 0.001), presence of systemic hypertension (β = 0.334, P = 0.001), and LDL (β = 0.199, P = 0.045) were independent factors significantly associated with the WLR. The increased retinal vessel wall thickness led to a narrowing of lumen diameter and a decrease in the blood flow in the PDR group.
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