Evidence map›Paper›PMID 33633241›Full record

ArticleScientific reports2021

Basement membrane proteins modulate cell migration on bovine pericardium extracellular matrix scaffold.

Qi Xing, Mojtaba Parvizi, Manuela Lopera Higuita, Leigh G Griffiths

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Qi XingDepartment of Cardiovascular Diseases, Mayo Clinic, Stabile 4-58, 200 First Street, Rochester, MN, 55905, USA.
Mojtaba ParviziDepartment of Cardiovascular Diseases, Mayo Clinic, Stabile 4-58, 200 First Street, Rochester, MN, 55905, USA.
Manuela Lopera HiguitaDepartment of Cardiovascular Diseases, Mayo Clinic, Stabile 4-58, 200 First Street, Rochester, MN, 55905, USA.
Leigh G GriffithsDepartment of Cardiovascular Diseases, Mayo Clinic, Stabile 4-58, 200 First Street, Rochester, MN, 55905, USA. Griffiths.Leigh@mayo.edu.
Mayo Clinic · US

Funding

Immunology of xenogeneic extracellular matrix scaffolds for heart valve tissue engineeringR01HL153098 · NHLBI · MAYO CLINIC ROCHESTER · PI GRIFFITHS, LEIGH GARETH · 2021 to 2024
$1.6M
Bimodal platform for nondestructive analysis of engineered vascular biomaterialsR01HL121068 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GRIFFITHS, LEIGH GARETH, MARCU, LAURA · 2015 to 2018
$1.5M
NHLBI NIH HHS R01 HL121068NHLBI NIH HHS R01 HL153098
6 · The paper itself

Abstract

Native bovine pericardium (BP) exhibits anisotropy of its surface ECM niches, with the serous surface (i.e., parietal pericardium) containing basement membrane components (e.g., Laminin, Col IV) and the fibrous surface (i.e., mediastinal side) being composed primarily of type I collagen (Col I). Native BP surface ECM niche anisotropy is preserved in antigen removed BP (AR-BP) extracellular matrix (ECM) scaffolds. By exploiting sideness (serous or fibrous surface) of AR-BP scaffolds, this study aims to determine the mechanism by which ECM niche influences human mesenchymal stem cells (hMSCs) migration. Human mesenchymal stem cells (hMSC) seeding on serous surface promoted more rapid cell migration than fibrous surface seeding. Gene analysis revealed that expression of integrin α

Indexed as

Cell MovementExtracellular MatrixMesenchymal Stem CellsPericardiumTissue ScaffoldsAnimalsAnisotropyBasement MembraneCattleCell ProliferationGene ExpressionHumansIntegrinsLamininIntegrinsLaminin

Identifiers

PMID33633241
PMCPMC7907089
OpenAlexW3129654472

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.