ArticleScientific reports2021
Mechanism of autonomous synchronization of the circadian KaiABC rhythm.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Physical Frameworks and Theories on How Autonomous Biological Oscillators Synchronize.Advances in experimental medicine and biology · 2026Review
- When lowering temperature, the in vivo circadian clock in cyanobacteria follows and surpasses the in vitro protein clock trough the Hopf bifurcation.Scientific reports · 2025Article
- Programming scheduled self-assembly of circadian materials.Nature communications · 2025Article
- Computation Implemented by the Interaction of Chemical Reaction, Clustering, and De-Clustering of Molecules.Biomimetics (Basel, Switzerland) · 2024Article
- Article
- Damped Oscillating Phosphoryl Transfer Reaction in the Cyanobacterial Circadian Clock.ACS omega · 2023Article
- Role of the reaction-structure coupling in temperature compensation of the KaiABC circadian rhythm.PLoS computational biology · 2022Article
- Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria.Science advances · 2022Article
- Beyond multi-disciplinary and cross-scale analyses of the cyanobacterial circadian clock system.Biophysics and physicobiology · 2021Article
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1 author.
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Abstract
The cyanobacterial circadian clock can be reconstituted by mixing three proteins, KaiA, KaiB, and KaiC, in vitro. In this protein mixture, oscillations of the phosphorylation level of KaiC molecules are synchronized to show the coherent oscillations of the ensemble of many molecules. However, the molecular mechanism of this synchronization has not yet been fully elucidated. In this paper, we explain a theoretical model that considers the multifold feedback relations among the structure and reactions of KaiC. The simulated KaiC hexamers show stochastic switch-like transitions at the level of single molecules, which are synchronized in the ensemble through the sequestration of KaiA into the KaiC-KaiB-KaiA complexes. The proposed mechanism quantitatively reproduces the synchronization that was observed by mixing two solutions oscillating in different phases. The model results suggest that biochemical assays with varying concentrations of KaiA or KaiB can be used to test this hypothesis.
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