Evidence map›Paper›PMID 33633218›Full record

SynthesisScientific reports2021

Correlation between circulating interleukin-18 level and systemic lupus erythematosus: a meta-analysis.

Mengmeng Xiang, Yang Feng, Yilun Wang, Jie Wang, Zhixiong Zhang, Jun Liang, Jinhua Xu

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. The Roles of Interleukin-18 in Inflammation and Autoimmune Disease.Clinical reviews in allergy & immunology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
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  9. Lupus Nephritis in Children: Novel Perspectives.Medicina (Kaunas, Lithuania) · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mengmeng XiangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Yang FengDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China. fengyangmd@126.com.
Yilun WangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jie WangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Zhixiong ZhangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Jun LiangDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China. Liangjun1976@medmail.com.cn.
Jinhua XuDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.
Huashan Hospital · CNFudan University · CNGuangzhou Institute of Dermatology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study is a meta-analysis aimed at pooling reported data and clarifying the association between circulating level of interleukin-18 and systemic lupus erythematosus (SLE). We searched medical databases including Medline/Pubmed, Embase, Scopus, The Cochrane Library, and Web of Science thoroughly to obtain all related articles published before July 15th, 2020. We pooled computed standardized mean difference (SMD) and its 95% confidence interval using STATA 13.0 and exhibited in the form of forest graph. Meta-regression and subgroup analysis were also performed to explore the source of heterogeneity. Publication bias was first evaluated by the symmetry of the funnel plot and then Egger's linear regression test. Thirty eligible studies from eighteen regions were finally included and the relevant data from these studies were pooled. The analysis results displayed that SLE patients showed a significantly higher level of circulating IL-18 level in comparison with healthy controls (SMD = 1.56, 95% CI [1.20-1.93]; I

Indexed as

AdultFemaleHumansInterleukin-18Linear ModelsLupus Erythematosus, SystemicMalePublication BiasIL18 protein, humanInterleukin-18

Identifiers

PMID33633218
PMCPMC7907126
OpenAlexW3129600654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.