ArticleScientific reports2021
Signatures of white-matter microstructure degradation during aging and its association with cognitive status.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.
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Who cites it
58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Neurofilament light chain as a promising biomarker for depression diagnosis: a systematic review and meta-analysis.BMC psychiatry · 2024Pooled it
- Magnetic resonance elastography of the ageing brain in normal and demented populations: A systematic review.Human brain mapping · 2022Pooled it
- Transcranial magnetic stimulation (TMS) for geriatric depression.Ageing research reviews · 2022Pooled it
- Article
- A Comparative Study of Aging and Cortical Folding in Chimpanzees and Olive Baboons.American journal of primatology · 2026Article
- Tract-specific white matter microstructure associated with early cognitive development in infants.Neuroimage. Reports · 2026Article
- A Comprehensive Characterization of the Phospholipid and Cholesterol Composition of the Uncinate Fasciculus in the Human Brain: Evidence of Age-Related Alterations.Journal of neurochemistry · 2026Article
- Differential tractography suggests a "left-to-whole" white matter degeneration pattern in aging.Brain imaging and behavior · 2026Article
- Similar minds age alike: an MRI similarity approach for predicting age-related cognitive decline.npj aging · 2026Article
- Review
- White matter microstructure changes across the lifespan: a meta-analysis of longitudinal diffusion MRI studies.bioRxiv : the preprint server for biology · 2025Article
- Local homeostasis preserves global neural dynamics compensating for structural loss during human lifespan aging.Communications biology · 2025Article
- Association between allostatic load and accelerated white matter brain aging: findings from the UK Biobank.American journal of epidemiology · 2025Article
- Glial Cells and Aging: From the CNS to the Cerebellum.International journal of molecular sciences · 2025Review
- Associations of Central Arterial Stiffness With Brain White Matter Integrity and Gray Matter Volume in MRI Across the Adult Lifespan.Journal of magnetic resonance imaging : JMRI · 2025Article
- Early subacute frontal callosal microstructure and language outcomes after stroke.Brain communications · 2025Article
- Assessing Exercise and Fitness-Related Brain Health Using Multi-modal Magnetic Resonance Imaging Outcomes.Advances in neurobiology · 2025Review
- Corpus callosum microstructure in chimpanzees (pan troglodytes): associations with age, handedness and cognition.Frontiers in aging neuroscience · 2025Article
- Understanding Cognitive Aging Through White Matter: A Fixel-Based Analysis.Human brain mapping · 2024Article
- The Impact of HIV on Early Brain Aging-A Pathophysiological (Re)View.Journal of clinical medicine · 2024Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have shown an association between cognitive decline and white matter integrity in aging. This led to the formulation of a "disconnection hypothesis" in the aging-brain, which states that the disruption in cortical network communication may explain the cognitive decline during aging. Although some longitudinal studies have already investigated the changes occurring in white matter microstructure, most focused on specific white matter tracts. Our study aims to characterize the longitudinal whole-brain signatures of white matter microstructural change during aging. Furthermore, we assessed the relationship between distinct longitudinal alterations in white matter integrity and cognition. White matter microstructural properties were estimated from diffusion magnetic resonance imaging, and cognitive status characterized from extensive neurocognitive testing. The same individuals were evaluated at two timepoints, with a mean interval time of 52.8 months (SD = 7.24) between first and last assessment. Our results show that age is associated with a decline in cognitive performance and a degradation in white matter integrity. Additionally, significant associations were found between diffusion measures and different cognitive dimensions (memory, executive function and general cognition). Overall, these results suggest that age-related cognitive decline is related to white matter alterations, and thus give support to the "disconnected hypothesis" of the aging brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.