ArticleScientific reports2021
Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- In-silico solute transport via perivascular networks in the human intracranial space.Nature communications · 2026Article
- Enhanced Taylor-Aris dispersion in slender pulsatile annular channels: Implications for perivascular solute transport.Journal of fluid mechanics · 2026Article
- Modeling glioma-induced impairments on the glymphatic system.Fluids and barriers of the CNS · 2026Article
- Article
- Enlarged perivascular spaces in the basal ganglia are associated with arteries not veins.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- A brain-wide solute transport model of the glymphatic system.Journal of the Royal Society, Interface · 2024Article
- Circadian Mechanisms in Brain Fluid Biology.Circulation research · 2024Review
- Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve.Fluids and barriers of the CNS · 2024Article
- Image-guided subject-specific modeling of glymphatic transport and amyloid deposition.Computer methods in applied mechanics and engineering · 2023Article
- Human brain solute transport quantified by glymphatic MRI-informed biophysics during sleep and sleep deprivation.Fluids and barriers of the CNS · 2023Article
- Perivascular network segmentations derived from high-field MRI and their implications for perivascular and parenchymal mass transport in the rat brain.Scientific reports · 2023Article
- Cerebrospinal Fluid Flow.Annual review of fluid mechanics · 2023Article
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
- Sensitivity analysis on a network model of glymphatic flow.Journal of the Royal Society, Interface · 2022Article
- A network model of glymphatic flow under different experimentally-motivated parametric scenarios.iScience · 2022Article
- Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model.Fluids and barriers of the CNS · 2022Article
- Fluid transport in the brain.Physiological reviews · 2022Review
- The glymphatic hypothesis: the theory and the evidence.Fluids and barriers of the CNS · 2022Review
- Simple analytic model for peristaltic flow and mixing.Physical review fluids · 2021Article
- Brain solute transport is more rapid in periarterial than perivenous spaces.Scientific reports · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Accumulation of metabolic wastes in the brain is correlated with several neurodegenerative disorders, including Alzheimer's disease. Waste transport and clearance occur via dispersion, the combined effect of diffusion and advection by flow of fluid. We examine the relative contributions of diffusion and advection in the perivascular spaces (PVSs) that surround penetrating cortical blood vessels and are filled with cerebrospinal fluid (CSF). To do so, we adapt prior analytic predictions of dispersion to the context of PVSs. We also perform advection-diffusion simulations in PVS-like geometries with parameters relevant to transport of amyloid-[Formula: see text] (associated with Alzheimer's) in a variety of flows, motivated by in vivo measurements. Specifically, we examine solute transport in steady and unsteady Poiseuille flows in an open (not porous) concentric circular annulus. We find that a purely oscillatory flow enhances dispersion only weakly and does not produce significant transport, whereas a steady flow component, even if slow, clears waste more effectively.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.