ArticleScientific reports2021
Exploring the conservation of Alzheimer-related pathways between H. sapiens and C. elegans: a network alignment approach.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
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- Mitochondrial Quality Control in Alzheimer's Disease: Insights fromAntioxidants (Basel, Switzerland) · 2024Review
- Special Issue "Alzheimer's Disease-115 Years after Its Discovery".Biomedicines · 2024Article
- A familial Alzheimer's disease associated mutation in presenilin-1 mediates amyloid-beta independent cell specific neurodegeneration.PloS one · 2024Article
- Clearance of extracellular human amyloid-β aggregates inmicroPublication biology · 2024Article
- Article
- Aligning Cross-Species Interactomes for Studying Complex and Chronic Diseases.Life (Basel, Switzerland) · 2023Article
- Structured Long-Chain Omega-3 Fatty Acids for Improvement of Cognitive Function during Aging.International journal of molecular sciences · 2022Review
- Modeling Alzheimer's Disease inBiomedicines · 2022Review
- Neuroprotective Effects of Oligosaccharides in Rehmanniae Radix on TransgenicFrontiers in pharmacology · 2022Article
- AnFrontiers in molecular neuroscience · 2022Article
- Biomolecule and Bioentity Interaction Databases in Systems Biology: A Comprehensive Review.Biomolecules · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer disease (AD) is a neurodegenerative disorder with an -as of yet- unclear etiology and pathogenesis. Research to unveil disease processes underlying AD often relies on the use of neurodegenerative disease model organisms, such as Caenorhabditis elegans. This study sought to identify biological pathways implicated in AD that are conserved in Homo sapiens and C. elegans. Protein-protein interaction networks were assembled for amyloid precursor protein (APP) and Tau in H. sapiens-two proteins whose aggregation is a hallmark in AD-and their orthologs APL-1 and PTL-1 for C. elegans. Global network alignment was used to compare these networks and determine similar, likely conserved, network regions. This comparison revealed that two prominent pathways, the APP-processing and the Tau-phosphorylation pathways, are highly conserved in both organisms. While the majority of interactions between proteins in those pathways are known to be associated with AD in human, they remain unexamined in C. elegans, signifying the need for their further investigation. In this work, we have highlighted conserved interactions related to AD in humans and have identified specific proteins that can act as targets for experimental studies in C. elegans, aiming to uncover the underlying mechanisms of AD.
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