ArticleScientific reports2021
Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in App
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Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
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Who cites it
48 citing papers in PubMed, 75 citations in OpenAlex.
- Effects of gonadectomy on brain sex hormone levels and amyloid pathology in male and female AppJournal of neuroendocrinology · 2026Article
- The impact of the Lab4 probiotic on neurodegenerative processes in a murine Alzheimer's disease model.Frontiers in neuroscience · 2026Article
- Diet, gut microbiome, and cognition in neurodegeneration: a review and methodological framework.Frontiers in aging neuroscience · 2026Review
- Identification of oxidative stress-associated biomarkers for inflammatory bowel disease through integrated machine learning and weighted gene co-expression network analysis.Frontiers in immunology · 2026Article
- Epigenetic and transcriptomic alterations precede amyloidosis in the Alzheimer's disease AppScientific reports · 2025Article
- Microbial metabolites as engines of behavioral variation across animals.Gut microbes · 2025Review
- Misclassification in memory modification ineLife · 2025Article
- Integrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy.Human genomics · 2025Observational
- Article
- Commonly prescribed multi-medication therapies exert sex-specific effects on Alzheimer's disease pathology and metabolomic profiles in AppAlzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Prenatal Stress Increases the Risk of the FPR2-related Dysfunction in the Brain's Resolution of Inflammation: A Study on the Humanized APPCurrent neuropharmacology · 2025Article
- Effects of West Nile virus on behavioral and cognitive performance, cortical Aβ pathology, viral loads, and immune measures of middle-aged NL-G-F/E3 and NL-G-F/E4 mice.Frontiers in aging neuroscience · 2025Article
- Modeling the zebrafish gut microbiome's resistance and sensitivity to climate change and parasite infection.Frontiers in microbiomes · 2025Article
- Article
- Maternal Gut Microbiome-Mediated Epigenetic Modifications in Cognitive Development and Impairments: A New Frontier for Therapeutic Innovation.Nutrients · 2024Review
- Review
- Navigating Alzheimer's Disease Mouse Models: Age-Related Pathology and Cognitive Deficits.Biomolecules · 2024Review
- Sexual dimorphism, altered hippocampal glutamatergic neurotransmission, and cognitive impairment in APP knock-in mice.Journal of Alzheimer's disease : JAD · 2024Article
- Sexual Dimorphism, Altered Hippocampal Glutamatergic Neurotransmission and Cognitive Impairment in APP Knock-In Mice.bioRxiv : the preprint server for biology · 2024Article
- Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Payel Kundu *Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97239, USA.
Eileen Ruth S Torres *Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97239, USA.
Keaton StagamanDepartment of Microbiology, Oregon State University, Corvallis, OR, 97331, USA.
Kristin KasschauDepartment of Microbiology, Oregon State University, Corvallis, OR, 97331, USA.
Mariam OkhovatDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
Sarah HoldenDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97239, USA.
Samantha WardDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
Kimberly A NevonenDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
Brett A DavisDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
Takashi SaitoDepartment of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, 467-8601, Japan.
Takaomi C SaidoLaboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.
Lucia CarboneDepartment of Medicine, Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR, 97239, USA.
Thomas J SharptonDepartment of Microbiology, Oregon State University, Corvallis, OR, 97331, USA.
Jacob RaberDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, 97239, USA. raberj@ohsu.edu.
Oregon Health & Science University · USOregon State University · USOregon National Primate Research Center · USNagoya City University · JPRIKEN Center for Brain Science · JP
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MMODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6MNeuroscience of Aging, Neurodegeneration and Alzheimer’s DiseaseT32AG055378 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI JACOB RABER, HENRYK F URBANSKI · 2018 to 2026
$4.3MEffects of apoE Isoform, Sex and Diet on Insulin Regulation in BrainRF1AG059088 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI BANKS, WILLIAM A, RABER, JACOB · 2018 to 2020
$2.5MImpacts of Benzo[a]pyrene on Microbiome Development across Lifespan and Generations and the Behavioral ConsequencesR01ES030226 · NIEHS · OREGON STATE UNIVERSITY · PI SHARPTON, THOMAS JEFFERSON · 2019 to 2023
$2.1MNeuronal activity modulation and age-related neurodegenerationR21AG065914 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI DANA, HOD MICHAEL, RABER, JACOB · 2020 to 2020
$695kIdentification of neuroprotective pathways of E2 against early and late onset hAPP/Ab-induced hippocampal injuryR56AG057495 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI RABER, JACOB · 2017 to 2017
$448kIdentification of markers of early epigenetic dysregulation in Alzheimer's diseaseR21AG065681 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI CARBONE, LUCIA · 2020 to 2020
$424kNIA NIH HHS R21 AG065681NIA NIH HHS R21 AG065914NIA NIH HHS R56 AG057495NIA NIH HHS RF1 AG059088NIA NIH HHS T32 AG055378NIEHS NIH HHS R01 ES030226NIEHS NIH HHS T32 ES007060NIH HHS P51 OD011092
Abstract
Epigenetic mechanisms occurring in the brain as well as alterations in the gut microbiome composition might contribute to Alzheimer's disease (AD). Human amyloid precursor protein knock-in (KI) mice contain the Swedish and Iberian mutations (App
Indexed as
Behavior, AnimalEpigenesis, GeneticGastrointestinal MicrobiomeAmyloid beta-Protein PrecursorAnimalsBody WeightConditioning, ClassicalDNA MethylationFearFemaleGenotypeHippocampusMiceMice, Inbred C57BLMice, TransgenicAmyloid beta-Protein Precursor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.