Evidence map›Paper›PMID 33633145›Full record

ArticleScientific reports2021

Machine learning based predictors for COVID-19 disease severity.

Dhruv Patel, Vikram Kher, Bhushan Desai, Xiaomeng Lei, Steven Cen, Neha Nanda, Ali Gholamrezanezhad, Vinay Duddalwar, Bino Varghese, Assad A Oberai

Registry-linked trialAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04834934 (Artificial Intelligence - SARS-CoV-2 Risk Evaluation), which is not on this map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04834934 completednot on this map

Artificial Intelligence - SARS-CoV-2 Risk Evaluation

TypeobservationalSponsorIRCCS San RaffaeleRan2020 to 2021Enrolled2,000ConditionsCovid19
3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dhruv PatelViterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Vikram KherViterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
Bhushan DesaiKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Xiaomeng LeiKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Steven CenKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Neha NandaKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ali GholamrezanezhadKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Vinay DuddalwarKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Bino VargheseKeck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Assad A OberaiViterbi School of Engineering, University of Southern California, Los Angeles, CA, USA. aoberai@usc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Predictors of the need for intensive care and mechanical ventilation can help healthcare systems in planning for surge capacity for COVID-19. We used socio-demographic data, clinical data, and blood panel profile data at the time of initial presentation to develop machine learning algorithms for predicting the need for intensive care and mechanical ventilation. Among the algorithms considered, the Random Forest classifier performed the best with [Formula: see text] for predicting ICU need and [Formula: see text] for predicting the need for mechanical ventilation. We also determined the most influential features in making this prediction, and concluded that all three categories of data are important. We determined the relative importance of blood panel profile data and noted that the AUC dropped by 0.12 units when this data was not included, thus indicating that it provided valuable information in predicting disease severity. Finally, we generated RF predictors with a reduced set of five features that retained the performance of the predictors trained on all features. These predictors, which rely only on quantitative data, are less prone to errors and subjectivity.

Indexed as

Machine LearningAdolescentAdultAgedAged, 80 and overCohort StudiesCOVID-19FemaleHumansIntensive Care UnitsMaleMiddle AgedPrognosisRisk FactorsSARS-CoV-2Severity of Illness Index

Identifiers

PMID33633145
PMCPMC7907061

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.