ArticleScientific reports2021
A matched irrigation and obturation strategy for root canal therapy.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Effect of Endodontic Irrigation on Mineral Content of Root Canal Dentine: A Systematic Review and Meta-Analysis.European endodontic journal · 2023Pooled it
- Herbal Agents versus Ethylene Diamine Tetra Acetic Acid on Removal of the Smear Layer-A Systematic Review of In Vitro Studies.International journal of environmental research and public health · 2022Pooled it
- An Updated Classification of Hydraulic Cements Used in Dentistry.International endodontic journal · 2026Review
- Effect of Novel All-in-One Root Canal Irrigants on Dislodgement Resistance of Epoxy Resin and Hydraulic Calcium Silicate Sealers: An Ex vivo Study.European journal of dentistry · 2026Article
- Shaping efficiency versus dentin conservation: a micro-CT taper-based analysis.Clinical oral investigations · 2026Article
- Effect of Root Canal Drying Methods on Bioceramic Sealer Bond Strength.Acta stomatologica Croatica · 2026Article
- Application of Amorphous Nanomaterials in Dentistry: A Comprehensive Review.Journal of functional biomaterials · 2025Review
- Assessment of a Light-Curable Hydrogel to Be Used for Root Canal Obturation.Journal of dental research · 2025Article
- The Effect of Irrigation Solutions on the Setting Time, Solubility, and pH of Three Types of Premixed Bioceramic-Based Root Canal Sealers.International journal of dentistry · 2025Article
- Effect of herbal irrigants on surface roughness of intraradicular dentin using quantitative method of 3D surface texture analysis.Scientific reports · 2024Article
- Advanced Materials for Clinical Endodontic Applications: Current Status and Future Directions.Journal of functional biomaterials · 2024Article
- Antibacterial and smear layer removal efficacy of moringa (Journal of Taibah University Medical Sciences · 2023Article
- Minimally invasive management of vital teeth requiring root canal therapy.Scientific reports · 2023Article
- A critical review of the material properties guiding the clinician's choice of root canal sealers.Clinical oral investigations · 2023Review
- Impact of Final Irrigation Protocol on the Push-Out Bond Strength of Two Types of Endodontic Sealers.Materials (Basel, Switzerland) · 2023Article
- Advances in the Role of Sodium Hypochlorite Irrigant in Chemical Preparation of Root Canal Treatment.BioMed research international · 2023Review
- Effect of Non-thermal Plasma Therapy on Pushout Bond Strength of Epoxy Resin and Tricalcium Silicate-Based Endodontic Sealers.Journal of lasers in medical sciences · 2023Article
- Cytotoxicity and Efficacy in Debris and Smear Layer Removal of HOCl-Based Irrigating Solution: An In Vitro Study.Journal of functional biomaterials · 2022Article
- The dentine-sealer interface: Modulation of antimicrobial effects by irrigation.International endodontic journal · 2022Article
- Successful root canal therapy during COVID-19 pandemic.Journal of dental sciences · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In root canal therapy, irrigating solutions are employed to eliminate the bacterial load and also prepare dentin for sealer interaction. The aim of this research was to assess how irrigating solutions employed on their own or in sequence affected the tooth structure. The best way to prepare the tooth for obturation using hydraulic calcium silicate cement (HCSC) sealers and gutta-percha, thus guiding clinicians on a matched irrigation-obturation strategy for optimized root canal treatment was investigated. The effect of irrigating solutions on dentine was investigated by assessing changes in dentin microhardness, ultrastructure and mineral content, organic/inorganic matter, surface roughness and Young's modulus. The interaction of four root canal sealers with the dentin was analysed by assessing the changes in microhardness of the dentin after sealer placement and also the sealer to dentin interface by scanning electron and confocal laser microscopy. The irrigating solutions damaged the dentin irreversibly both when used on their own and in combination. The best sequence involved sodium hypochlorite followed by chelator and a final rinse with sodium hypochlorite and obturation using HCSC sealers that enabled the restoration of dentin properties. The HCSC sealers did not rely on chelator irrigating solutions for a good material adaptation to dentin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.