ArticleTurkish journal of pharmaceutical sciences2021
Development of a Novel Freeze-dried Mulberry Leaf Extract-based Transfersome Gel.
Article in Turkish journal of pharmaceutical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 25 citations in OpenAlex.
- Recent Advances in Mulberry Processing and Drying Technologies: A Comprehensive Review.Foods (Basel, Switzerland) · 2026Review
- Transferosomes as Advanced Nanocarriers for Enhanced Drug Delivery in Skin Cancer Therapy: A Comprehensive Review.Applied biochemistry and biotechnology · 2026Review
- Advances in Transdermal Drug Delivery Systems and Clinical Applications in Inflammatory Skin Diseases.Pharmaceutics · 2025Review
- Vesicular Carriers for Phytochemical Delivery: A Comprehensive Review of Techniques and Applications.Pharmaceutics · 2025Review
- Unravelling the success of transferosomes against skin cancer: Journey so far and road ahead.Drug delivery and translational research · 2024Review
- Transfersome, an ultra-deformable lipid-based drug nanocarrier: an updated review with therapeutic applications.Naunyn-Schmiedeberg's archives of pharmacology · 2024Review
- Tea Tree Oil: Properties and the Therapeutic Approach to Acne-A Review.Antioxidants (Basel, Switzerland) · 2023Review
- Preparation, Characterization and Permeation Study of Topical Gel Loaded with Transfersomes Containing Asiatic Acid.Molecules (Basel, Switzerland) · 2022Article
- Self-Assembling Drug Formulations with Tunable Permeability and Biodegradability.Molecules (Basel, Switzerland) · 2021Review
- Phytosomes as Innovative Delivery Systems for Phytochemicals: A Comprehensive Review of Literature.International journal of nanomedicine · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesNowadays, antioxidants are important for health-related concerns related to acne vulgaris. Acne vulgaris is interrelated with the development of free radicals that interact with cells. Mulberry leaves contain phenolic compounds, including antioxidants such as quercetin. An antioxidant is a scavenger of free radicals. The current study addresses the development of a mulberry leaf extract-based transfersome gel containing quercetin by a thin-layer hydration method for topical antioxidant delivery. The process was optimized by encapsulating the drug in a variety of transfersome formulations. MATERIALS AND
methodsBatch optimization was carried out by particle size and zeta analysis, entrapment efficiency (%), polydispersity index,
resultsThe optimized batch MF5 provided 86.23% entrapment efficiency of quercetin in the vesicles and 95.79% drug release. It furnished a spherical shaped vesicle with an average diameter of 118.7 nm and zeta potential of -45.11 mV. The MG1 formulation provided superior antioxidant activity, drug content, and entrapment efficiency,
conclusionIt is evident from this study that a mulberry leaf extract-based transfersome gel is a promising prolonged delivery system for quercetin and has reasonably good stability characteristics. This research recommends that mulberry leaf extract-based transfersome gel can potentially be used in the treatment of acne vulgaris through a transdermal drug delivery system.
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