Evidence map›Paper›PMID 33632931›Full record

SynthesisPediatrics2021

Umbilical Cord Management for Newborns <34 Weeks' Gestation: A Meta-analysis.

Anna Lene Seidler, Gillian M L Gyte, Heike Rabe, José L Díaz-Rossello, Lelia Duley, Khalid Aziz, Daniela Testoni Costa-Nobre, Peter G Davis, Georg M Schmölzer, Colleen Ovelman and 3 more

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06737965 (Cardiovascular Immaturity in Extremely Low Gestational Age Newborns), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06737965 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Cardiovascular Immaturity in Extremely Low Gestational Age Newborns: a Fundamental Prospective Study

TypeobservationalSponsorUniversity Hospital, MontpellierRan2025 to 2025Enrolled15ConditionsELGAN (22-28SA), Extremely Low Gestational Age Newborns, Cardiovascular ImmaturityArmsMedical abortion, Foetopathology exam, Outcomes mesurement
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Trial
  6. Care of the Newborn and Cord During the Third Stage of Labour (Scientific Impact Paper No. 78).BJOG : an international journal of obstetrics and gynaecology · 2026
    Review
  7. Article
  8. Observational
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Maternal implications of placental transfusion.Seminars in perinatology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 7 countries.

Anna Lene SeidlerNational Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia; lene.seidler@ctc.usyd.edu.au.
Gillian M L GyteCochrane Pregnancy and Childbirth Group, University of Liverpool, Liverpool, United Kingdom.
Heike RabeAcademic Department of Paediatrics, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom.
José L Díaz-RosselloDepartamento de Neonatologia del Hospital de Clínicas, Universidad de la Republica, Montevideo, Uruguay.
Lelia DuleyNottingham Clinical Trials Unit, University of Nottingham, Nottingham, United Kingdom.
Khalid AzizDepartment of Pediatrics, University of Alberta, Edmonton, Canada.
Daniela Testoni Costa-NobreDepartment of Paediatrics, Universidade Federal de São Paulo, São Paulo, Brazil.
Peter G DavisNewborn Research Centre, The Royal Women's Hospital and The University of Melbourne, Melbourne, Victoria, Australia.
Georg M SchmölzerDivision of Neonatology, Department of Pediatrics, Medical University Graz, Graz, Austria.
Colleen OvelmanDepartment of Pediatrics, The Robert Larner College of Medicine, The University of Vermont, Burlington, Vermont; and.
Lisa M AskieNational Health and Medical Research Council Clinical Trials Centre, University of Sydney, Sydney, Australia.
Roger SollDepartment of Pediatrics, The Robert Larner College of Medicine, The University of Vermont, Burlington, Vermont; and.
INTERNATIONAL LIAISON COMMITTEE ON RESUSCITATION NEONATAL LIFE SUPPORT TASK FORCE
University of Sydney · AUUniversity of Vermont · USBrighton and Sussex Medical School · GBHospital de Clínicas · UYMedical University of Graz · ATRoyal Women's Hospital · AUUniversidade Federal de São Paulo · BRUniversity of Alberta · CAUniversity of Liverpool · GBUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

contextThe International Liaison Committee on Resuscitation prioritized scientific review of umbilical cord management strategies at preterm birth.

objectiveTo determine the effects of umbilical cord management strategies (including timing of cord clamping and cord milking) in preterm infants <34 weeks' gestation. DATA SOURCES: Cochrane Central Register of Controlled Trials, Medline, PubMed, Embase, CINAHL, and trial registries were searched through July 2019 for randomized controlled trials assessing timing of cord clamping and/or cord milking. STUDY SELECTION: Two authors independently assessed trial eligibility, extracted data, appraised risk of bias, and assessed evidence certainty (GRADE). DATA EXTRACTION: We identified 42 randomized controlled trials (including 5772 infants) investigating 4 different comparisons of cord management interventions.

resultsCompared to early cord clamping, delayed cord clamping (DCC) and intact-cord milking (ICM) may slightly improve survival; however, both are compatible with no effect (DCC: risk ratio: 1.02, 95% confidence interval: 1.00 to 1.04, LIMITATIONS: For many of the included comparisons and outcomes, certainty of evidence was low. Our subgroup analyses were limited by few researchers reporting subgroup data.

conclusionsDCC appears to be associated with some benefit for infants born <34 weeks. Cord milking needs further evidence to determine potential benefits or harms. The ideal cord management strategy for preterm infants is still unknown, but early clamping may be harmful.

Indexed as

Fetal BloodPremature BirthUmbilical CordBiasConfidence IntervalsConstrictionHumansInfant, NewbornInfant, PrematureRandomized Controlled Trials as TopicTime Factors

Identifiers

PMID33632931
PMCPMC7924139
OpenAlexW3132009786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.