Evidence map›Paper›PMID 33632754›Full record

ArticleBMJ open2021

Impact of COVID-19 on female fertility: a systematic review and meta-analysis protocol.

Fangyuan Li, Hua Lu, Qi Zhang, Xinyun Li, Tong Wang, Qianchen Liu, Qian Yang, Lingxia Qiang

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05435430 (Post-COVID-19 Infection and Reproductive Health in Women Undergoing I.V.F. Treatment), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05435430 unknown statusnot on this mapstarted 2022, after this paper: background citation

Post-COVID-19 Infection and Reproductive Health in Women Undergoing I.V.F. Treatment

TypeobservationalSponsorUniversity of PalermoRan2022 to 2024Enrolled150ConditionsInfertility, FemaleArmsPERSPECTIVE, MULTICENTRIC and observational
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Impact of COVID-19 on fertility and assisted reproductive technology (ART): a systematic review.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Observational
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Covid-19 vaccination and menstrual cycle length in the Apple Women's Health Study.medRxiv : the preprint server for health sciences · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fangyuan LiHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Hua LuHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China lh18980880525@126.com.ORCID 0000-0002-2709-222X
Qi ZhangHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Xinyun LiHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Tong WangHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Qianchen LiuHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Qian YangHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Lingxia QiangHospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chengdu University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe increased social and economic burden caused by the novel COVID-19 outbreak is gradually becoming a worrisome issue for the health sector. The novel coronavirus invades the target cell by binding to ACE2, which is widely expressed in the ovaries, uterus, vagina and placenta. Significantly, the SARS-CoV-2 is said to interrupt female fertility through regulating ACE2. Thus, it is essential to investigate if the novel COVID-19 hampers female fertility, given that there is no systematic and comprehensive evidence on the association of COVID-19 with female fertility. METHODS AND ANALYSIS: We will systematically search cohort studies, cross-sectional studies, case-control studies and self-controlled case series designs in the following databases: Web of Science, PubMed, EMBASE, Cochrane Library, Ovid, EBSCO, WHO COVID-19 Database, Chinese Biomedical Databases, China National Knowledge Internet, VIP and WanFang Database. Medical Subject Headings and free-text terms for "COVID-19" AND "female" AND "fertility" will be performed. Eligibility criteria are as follows: population (female patients aged 13-49 years); exposure (infection with SARS-CoV-2); comparison (population without SARS-CoV-2 infections or latent SARS-CoV-2 infections); and outcome (female fertility, such as ovarian reserve function, uterine receptivity, oviducts status and menstruation status). Article screening and data extraction will be undertaken independently by two reviewers, and discrepancies will be resolved through discussion. We will use the I ETHICS AND DISSEMINATION: Formal ethical approval is not required, and findings will be published in a peer-reviewed journal. PROSPERO REGISTRATION NUMBER: CRD42020189856.

Indexed as

FertilityResearch DesignAdolescentAdultChinaCOVID-19FemaleHumansMeta-Analysis as TopicMiddle AgedPregnancySystematic Reviews as TopicYoung AdultCOVID-19epidemiologygynaecology

Identifiers

PMID33632754
PMCPMC7908052
OpenAlexW3129965040

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.