SynthesisStroke and vascular neurology2021
Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack.
Synthesis in Stroke and vascular neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prognostic value of the C-reactive protein to albumin ratio in patients with stroke: a meta-analysis.Scientific reports · 2025Pooled it
- Pooled it
- Serum Albumin and Post-Stroke Outcomes: Analysis of UK Regional Registry Data, Systematic Review, and Meta-Analysis.Nutrients · 2024Pooled it
- Added Value of One-Month Clinical Data in Predicting Chronic-Stage Motor Function After Ischemic Stroke.Journal of clinical medicine · 2026Article
- Real-World Outcomes of Ischemic Stroke Interventions in Older Patients: A Cohort Study from a Tertiary Medical Center.Healthcare (Basel, Switzerland) · 2026Article
- Albumin levels and risk of early cardiovascular complications after endovascular thrombectomy for acute ischaemic stroke.Scientific reports · 2026Article
- Neuroprotective mechanisms of cobalamin in ischemic stroke insights from network pharmacology and molecular simulations.Scientific reports · 2026Article
- Monocyte-to-Albumin Ratio (MAR) Is Associated With All-Cause Mortality in Adult Stroke Patients: Evidence From NHANES (1999-2018).Stroke research and treatment · 2026Article
- Dynamic albumin-to-RDW trajectories for time-dependent risk stratification in acute brain injury.Frontiers in nutrition · 2026Article
- Lactate/albumin ratio predicts 90-day mortality of cardiogenic shock patients.Open medicine (Warsaw, Poland) · 2026Article
- Association between lactate-to-albumin ratio and in-hospital mortality in ICU patients with acute ischemic stroke: a retrospective cohort study.Frontiers in neurology · 2026Article
- Association between comprehensive dietary antioxidant index and stroke: mediating role of oxidative stress.Journal of clinical biochemistry and nutrition · 2026Article
- Sex Modifies the Association Between Neutrophil Percentage-to-Albumin Ratio and Stroke-Associated Pneumonia in Acute Ischemic Stroke.Journal of inflammation research · 2026Article
- The association between acute nutritional changes and prognosis in ischemic stroke patients.Frontiers in nutrition · 2026Article
- Predictive value of preoperative and postoperative controlling nutritional status scores and their changes in older patients with large vessel occlusion stroke after endovascular thrombectomy.Frontiers in nutrition · 2026Article
- Association Between the Geriatric Nutritional Risk Index and All-Cause Mortality in Elderly Patients with Acute Ischemic Stroke After Intravenous Thrombolysis.International journal of general medicine · 2026Article
- Serum prealbumin at admission is associated with post-stroke depression at 3 months in patients with spontaneous intracerebral hemorrhage.Frontiers in psychiatry · 2026Article
- Association between ALBI score and stroke risk and all-cause mortality: 2011 to 2018 NHANES.Medicine · 2025Article
- Inflammatory Semaphorins in the Pathogenesis and Prognosis of Acute Ischemic Stroke.Medicina (Kaunas, Lithuania) · 2025Article
- Observational
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo examine the relationship of serum albumin with poor functional outcome and mortality in patients with acute ischaemic stroke (AIS) or transient ischaemic attack (TIA), and perform a meta-analysis to summarise the association.
methodsWe analysed data from the Third China National Stroke Registry (CNSR-Ⅲ). Patients were divided into four groups based on serum albumin levels at admission. The outcomes included poor functional outcome (modified Rankin Scale (mRS) score of 3 to 6) and mortality at 3 months and 1 year. Multiple logistic regression models and Cox regression models were used to evaluate the association, respectively. We used a fixed-effect model to calculate the risk ratio for poor functional outcome and a random-effect model for mortality in the meta-analysis.
resultsA total of 13 618 patients were enrolled. During the 3-month follow-up period, compared with 40 to 44.9 g/L group, patients in <35 g/L group had an increased risk of poor functional outcome and mortality (adjusted OR 1.37 (95% CI 1.12 to 1.67); adjusted HR 2.13 (95% CI 1.41 to 3.23)). The relationship in per 10 g/L decreased serum albumin with prognosis was consistently inversed (adjusted OR 1.17 (95% CI 1.01 to 1.35); adjusted HR 1.86 (95% CI 1.30 to 2.64)). Also, low serum albumin levels were independently correlated with clinical outcomes at 1 year. In the meta-analysis, the OR for poor functional outcome pooled 3 studies per 1 g/L decrease was 1.03 (95% CI 1.02 to 1.05), and the HR for mortality pooled 5 studies was 1.07 (95% CI 1.03 to 1.11).
conclusionsLow serum albumin levels predict poor functional outcome and mortality in patients with AIS or TIA.
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