SynthesisGut2021
Genetic architectures of proximal and distal colorectal cancer are partly distinct.
Registry-linked trialOpen access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Gut, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 53 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 4 pooled it
9.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis
Who cites it
53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Genetically determined circulating resistin concentrations and risk of colorectal cancer: a two-sample Mendelian randomization study.Journal of cancer research and clinical oncology · 2023Pooled it
- Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Pooled it
- Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.BMC medicine · 2023Pooled it
- Pooled it
- Article
- Enterotoxigenic Bacteroides fragilis Induces Host Genotype-Specific Colonic Epithelial and Immune Responses in Mice.The Journal of infectious diseases · 2026Article
- Combining machine learning and multi-omics analysis to explore the role of CPT1C in colorectal tumor cancer transformation.Scientific reports · 2026Article
- MyGeneRisk Colon: A Web-Based Tool for Personalized Colorectal Cancer Risk Prediction Based on Genetics and Lifestyle.medRxiv : the preprint server for health sciences · 2026Article
- A Swedish Haplotype GWAS in Familial and Sporadic Site-Specific Colorectal Cancer.International journal of molecular sciences · 2026Article
- Gene, genetics and genetic medicines in gastroenterology: Current status and its future.World journal of gastroenterology · 2026Review
- Distinct Molecular and Prognostic Profiles of Left- and Right-Sided Colorectal Cancer Revealed by NGS Analysis: The Role of SMAD4 and SETD2 Mutations.Cancer medicine · 2026Article
- Diagnostic Relevance of miR-185, miR-141, and miR-21 in Colon Carcinoma: Insights into Tumor Sidedness and Reference Gene Selection.Biomedicines · 2025Article
- Transcriptome-wide Mendelian randomization exploring dynamic CD4+ T cell gene expression in colorectal cancer development.Journal of leukocyte biology · 2025Article
- Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes.Nature communications · 2025Article
- Transcriptome-wide Mendelian randomisation exploring dynamic CD4+ T cell gene expression in colorectal cancer development.medRxiv : the preprint server for health sciences · 2025Article
- Commentary: Special Issue: Current Understanding of Colorectal and Pancreatic Cancers.Mutagenesis · 2025Article
- Exploring the Chemopreventive Effect of Medication on Gene Expression Linked to Colorectal Cancer: An Observational and Mendelian Randomization Analysis in Healthy Colon Mucosa.International journal of molecular sciences · 2024Observational
- Charting the metabolic biogeography of the colorectum in cancer: challenging the right sided versus left sided classification.Molecular cancer · 2024Article
- Prognostic and Predictive Significance of Primary Tumor Localization and HER2 Expression in the Treatment of Patients with KRAS Wild-Type Metastatic Colorectal Cancer: Single-Centre Experience from Serbia.Journal of personalized medicine · 2024Article
- Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum.World journal of gastrointestinal oncology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
141 authors at 20 institutions in 17 countries.
Jeroen R HuyghePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.ORCID 0000-0001-6027-9806
Tabitha A HarrisonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Stephanie A BienPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Heather HampelDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Jane C FigueiredoDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Stephanie L SchmitGenomic Medicine Institute, Cleveland Clinic, Cleveland, Ohio, USA.
David V ContiDepartment of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Sai ChenDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Conghui QuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Richard BarfieldPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
John A BaronDepartment of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Amanda J CrossDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Brenda DiergaardeDepartment of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
David DugganTranslational Genomics Research Institute - An Affiliate of City of Hope, Phoenix, Arizona, USA.
Sophia HarlidDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Liher ImazPublic Health Division of Gipuzkoa, Health Department of Basque Country, San Sebastian, Spain.
Hyun Min KangDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
David M LevineDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Vittorio PerducaLaboratoire de Mathématiques Appliquées MAP5 (UMR CNRS 8145), Université Paris Descartes, Paris, France.
Aurora Perez-CornagoCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Lori C SakodaPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Fredrick R SchumacherDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
Martha L SlatteryDepartment of Internal Medicine, University of Utah Health, Salt Lake City, Utah, USA.
Amanda E TolandDepartments of Cancer Biology and Genetics and Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Fränzel J B van DuijnhovenDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Antonio AgudoUnit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
M Henar AlonsoCancer Prevention and Control Program, Catalan Institute of Oncology - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Kristin AndersonDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Coral Arnau-CollellGastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Barbara L BanburyPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Michael C BassikDepartment of Genetics, Stanford University, Stanford, California, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Stéphane BézieauService de Génétique Médicale, Centre Hospitalier Universitaire (CHU) de Nantes, Nantes, France.
D Timothy BishopLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
Juergen BoehmHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah Health, Salt Lake City, Utah, USA.
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Germany.
Marie-Christine Boutron-RuaultCentre for Research in Epidemiology and Population Health (CESP), Institut pour la Santé et la Recherche Médicale (INSERM) U1018, Université Paris-Saclay, Villejuif, France.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany.ORCID 0000-0002-6129-1572
Stefanie BrezinaInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Stephan BuchDepartment of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.
Daniel D BuchananCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-2225-6675
Andrea Burnett-HartmanInstitute for Health Research, Kaiser Permanente Colorado, Denver, Colorado, USA.
Bette J CaanDivision of Research, Kaiser Permanente Medical Care Program, Oakland, California, USA.
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia, USA.
Prudence R CarrDivision of Clinical Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Antoni CastellsGastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
Sergi Castellví-BelGastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-7284-6767
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Keith R CurtisPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Albert de la ChapelleDepartment of Cancer Biology and Genetics and the Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Douglas F EastonDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Dallas R EnglishCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Edith J M FeskensDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.
Manish GalaDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Steven J GallingerLunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
W James GaudermanDepartment of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
William M GradyClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
John S GroveUniversity of Hawai'i Cancer Center, Honolulu, Hawaii, USA.
Andrea GsurInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-9795-1528
Marc J GunterNutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Robert W HaileDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Jochen HampeDepartment of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.ORCID 0000-0002-2421-6127
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8307-3197
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Wan-Ling HsuDepartment of Biostatistics, University of Washington, Seattle, Washington, USA.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.ORCID 0000-0002-4440-3368
Thomas J HudsonOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Mazda JenabNutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID 0000-0002-0573-1852
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Amit D JoshiClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Temitope O KekuCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina, USA.
Charles KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Sébastien KüryService de Génétique Médicale, Centre Hospitalier Universitaire (CHU) de Nantes, Nantes, France.
Loic Le MarchandUniversity of Hawai'i Cancer Center, Honolulu, Hawaii, USA.
Flavio LejbkowiczThe Clalit Health Services, Personalized Genomic Service, Carmel Medical Center, Haifa, Israel.
Christopher I LiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Li LiDepartment of Family Medicine, University of Virginia, Charlottesville, Virginia, USA.
Wolfgang LiebInstitute of Epidemiology, PopGen Biobank, Christian-Albrechts-University Kiel, Kiel, Germany.
Annika LindblomDepartment of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Noralane M LindorDepartment of Health Science Research, Mayo Clinic, Scottsdale, Arizona, USA.
Satu MännistöDepartment of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
Sanford D MarkowitzDepartments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio, USA.
Roger L MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Lorena MorenoGastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
Neil MurphyNutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.ORCID 0000-0003-3347-8249
Rami NassirDepartment of Pathology, School of Medicine, Umm Al-Qura'a University, Mecca, Saudi Arabia.
Kenneth OffitClinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Shuji OginoBroad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Salvatore PanicoDipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, Naples, Italy.
Patrick S ParfreyClinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
Rachel PearlmanDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
Paul D P PharoahDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Amanda I PhippsPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Ross L PrenticePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Lihong QiDepartment of Public Health Sciences, School of Medicine, University of California Davis, Davis, California, USA.
Leon RaskinDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Gad RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Hedy S RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Elio RiboliSchool of Public Health, Imperial College London, London, UK.
Clemens SchafmayerDepartment of General Surgery, University Hospital Rostock, Rostock, Germany.
Robert E SchoenDepartment of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Daniela SeminaraDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland, USA.
Mingyang SongDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Yu-Ru SuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Catherine M TangenSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Stephen N ThibodeauDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, MayoClinic, Rochester, Minnesota, USA.
Duncan C ThomasDepartment of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Cornelia M UlrichHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah Health, Salt Lake City, Utah, USA.
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
Pavel VodickaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Ludmila VodickovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Veronika VymetalkovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Korbinian WeiglDivision of Clinical Epidemiology and Aging Research, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Michael O WoodsDiscipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
Anna H WuDepartment of Preventive Medicine and USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Goncalo R AbecasisDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, Washington, USA.
Peter C ScacheriDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.
Anshul KundajeDepartment of Genetics, Stanford University, Stanford, California, USA.
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.
Stephen B GruberDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Victor MorenoCancer Prevention and Control Program, Catalan Institute of Oncology - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Richard B HayesDivision of Epidemiology, Department of Population Health, New York University School of Medicine, New York, New York, USA.
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA upeters@fhcrc.org.ORCID 0000-0001-5666-9318
Fred Hutch Cancer Center · USUniversity of Washington · USGerman Cancer Research Center · DENational Cancer Institute · USUniversity of Southern California · USThe University of Melbourne · AUCentro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas · ESThe Ohio State University · USCentre international de recherche sur le cancer · FRCharles University · CZHarvard University · USInstitut d'Investigació Biomédica de Bellvitge · ESKaiser Permanente · USUniversity of Michigan · USUniversity of Utah · USBroad Institute · USCentre Hospitalier Universitaire de Nantes · FRImperial College London · GBJohns Hopkins University · USMedical University of Vienna · AT
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MTranslational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4MSWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2MStaff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9MSWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MStatistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ROSNER, BERNARD A · 2000 to 2019
$77.8MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MMolecular pathological epidemiology of colorectal cancerU01CA137088 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2009 to 2018
$21.8MTransdisciplinary Team Science in Colorectal Cancer Prognosis: the ColoCare StudyU01CA206110 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jane C. Figueiredo, Christopher I Li · 2016 to 2026
$18.6MData sharing: the Colon Cancer Family Registry CohortU01CA167551 · NCI · UNIVERSITY OF MELBOURNE · PI Daniel David BUCHANAN, Steven Gallinger · 2018 to 2026
$16.8MDetection of Colorectal Cancer Susceptibility Loci Using Genome-Wide SequencingU01CA164930 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PETERS, ULRIKE · 2012 to 2015
$12.4MCancer Research UK 16561Cancer Research UK 19167Cancer Research UK 25004NCI NIH HHS K07 CA190673NCI NIH HHS K99 CA158141NCI NIH HHS P01 CA087969NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA093373NCI NIH HHS R00 CA158141NCI NIH HHS R01 CA042182NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA143237NCI NIH HHS R01 CA151993NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA207371NCI NIH HHS R21 CA191312NCI NIH HHS R35 CA197735NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA182883NCI NIH HHS U01 CA206110NCI NIH HHS U10 CA037429NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA182883NCI NIH HHS UM1 CA186107NHLBI NIH HHS HHSN268201200008CNHLBI NIH HHS HHSN268201200008IWorld Health Organization 001
Abstract
objectiveAn understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics and environmental risk factors among tumors arising in different locations of the colorectum suggest partly distinct mechanisms of carcinogenesis. The extent to which the contribution of inherited genetic risk factors for CRC differs by anatomical subsite of the primary tumor has not been examined.
designTo identify new anatomical subsite-specific risk loci, we performed genome-wide association study (GWAS) meta-analyses including data of 48 214 CRC cases and 64 159 controls of European ancestry. We characterised effect heterogeneity at CRC risk loci using multinomial modelling.
resultsWe identified 13 loci that reached genome-wide significance (p<5×10
conclusionGenetic architectures of proximal and distal CRC are partly distinct. Studies of risk factors and mechanisms of carcinogenesis, and precision prevention strategies should take into consideration the anatomical subsite of the tumour.
Indexed as
ColonGenetic HeterogeneityAdultAgedAged, 80 and overAge DistributionAge of OnsetAllelesCase-Control StudiesCecumColon, AscendingColon, DescendingColonic NeoplasmsColon, SigmoidColon, TransverseFemalecancer geneticscancer susceptibilitycolon carcinogenesiscolorectal cancergenetic polymorphisms
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
NCT02328677ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.