ArticleBMJ open diabetes research & care2021
Bidirectional temporal relationship between obesity and hyperinsulinemia: longitudinal observation from a Chinese cohort.
Article in BMJ open diabetes research & care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Hyperinsulinaemia as a cause of obesity and cardiometabolic diseases.Nature reviews. Endocrinology · 2026Review
- Effect of stress on insulin resistance among shift workers based on findings from the Korea National Health and Nutrition Examination Survey (2019, 2021): a retrospective cross-sectional study.Journal of Korean biological nursing science · 2026Article
- Article
- Risk Factors and Cumulative Risk of Comorbid Myopia and Obesity Among Children and Adolescents in Southern China: A Cross-Sectional Study.Health science reports · 2025Article
- Alterations in Adipose Tissue Distribution, Cell Morphology, and Function Mark Primary Insulin Hypersecretion in Youth With Obesity.Diabetes · 2024Article
- 10-year level, trends and socio-demographic disparities of obesity among Ghanaian adults-A systematic review and meta-analysis of observational studies.PLOS global public health · 2024Article
- Empirical dietary inflammatory index and lifestyle inflammation score relationship with obesity: A population-based cross-sectional study.Food science & nutrition · 2023Article
- Remnant cholesterol, stronger than triglycerides, is associated with incident non-alcoholic fatty liver disease.Frontiers in endocrinology · 2023Article
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Authors and funding
10 authors.
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Abstract
introductionAlthough obesity and hyperinsulinemia are closely intercorrelated, their temporal sequence is still uncertain. This study aims to investigate the temporal relationship patterns between obesity measures and hyperinsulinemia in Chinese adults. RESEARCH DESIGN AND
methodsThe longitudinal cohort consisted of 2493 participants (860 males and 1633 female, mean age 56.71 years at follow-up) for whom measurements of obesity and hyperinsulinemia measures were collected twice between 2011 and 2014, with an average follow-up time of 3 years. Cross-lagged panel analysis was used to examine the temporal relationship between obesity measures (body mass index (BMI); waist circumference (WC); hip circumference (HC); waist-to-hip ratio (WHR)) and hyperinsulinemia (insulin, homeostasis model assessment of insulin resistance (HOMA-IR), or homeostasis model assessment of beta cell function (HOMA-%β)).
resultsAfter the adjustment of age, sex, smoking, drinking and follow-up years, in the BMI-insulin model, the path coefficient (β
conclusionsThese findings indicate that there is a bidirectional relationship between obesity and hyperinsulinemia, and abdominal obesity measures are more sensitive to hyperinsulinemia measures than BMI.
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