Evidence map›Paper›PMID 33632603›Full record

ReviewTrends in microbiology2021

Inorganic polyphosphate in host and microbe biology.

Marvin Q Bowlin, Michael J Gray

Open access · greenAbstract readReview
In one paragraph

Review in Trends in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Article
  3. The roles and synthesis of inorganic polyphosphate inbioRxiv : the preprint server for biology · 2026
    Article
  4. Polyphosphate synthesis is essential for phosphate and ATP homeostasis during nutrient upshift.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Inorganic Polyphosphate and Human Diseases.Progress in molecular and subcellular biology · 2026
    Review
  10. Factor XII-driven coagulation traps bacterial infections.The Journal of experimental medicine · 2025
    Article
  11. Article
  12. Review
  13. Polyphosphate: a cellular Swiss army knife.Current opinion in biotechnology · 2025
    Review
  14. Article
  15. Antioxidants (Basel, Switzerland) · 2025
    Article
  16. The microbial phosphorus cycle in aquatic ecosystems.Nature reviews. Microbiology · 2025
    Review
  17. Review
  18. Article
  19. mSphere · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Marvin Q BowlinDepartment of Microbiology, School of Medicine, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294, USA.
Michael J GrayDepartment of Microbiology, School of Medicine, University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294, USA. Electronic address: mjgray@uab.edu.
University of Alabama at Birmingham · US

Funding

Molecular Mechanisms of Bacterial Stress Response Relevant to Host-Microbe InteractionsR35GM124590 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael Jeffrey Gray · 2017 to 2026
$3.5M
NIGMS NIH HHS R35 GM124590
6 · The paper itself

Abstract

Inorganic polyphosphate (polyP) is produced by both bacteria and their eukaryotic hosts, and it appears to play multiple important roles in the interactions between those organisms. However, the detailed mechanisms of how polyP synthesis is regulated in bacteria, and how it influences both bacterial and host biology, remain largely unexplored. In this review, we examine recent developments in the understanding of how bacteria regulate the synthesis of polyP, what roles polyP plays in controlling virulence in pathogenic bacteria, and the effects of polyP on the mammalian immune system, as well as progress on developing drugs that may be able to target bacterial polyP synthesis as novel means of treating infectious disease.

Indexed as

BacteriaPolyphosphatesAnimalsBiologyMammalsVirulencePolyphosphatesbacterial survivalimmune regulationpathogenicitypolyphosphate

Identifiers

PMID33632603
PMCPMC8380261
OpenAlexW3129277148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.