ArticleJournal of the American College of Cardiology2021
Comparison of Management Strategies for Neonates With Symptomatic Tetralogy of Fallot.
Article in Journal of the American College of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06081855 (Predictors of Aortic Root Dilatation in Tetralogy of Fallot Patients), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Predictors of Aortic Root Dilatation in Tetralogy of Fallot Patients
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Outcomes of Primary Vs. Staged Repair in 4628 Neonates with Symptomatic Tetralogy of Fallot: A Systematic Review and Meta-analysis.Pediatric cardiology · 2026Pooled it
- Managing cyanotic neonates with tetralogy of Fallot: A national perspective on surgical approaches.JTCVS open · 2026Article
- ECG Changes in Tetralogy of Fallot: Association with Right Ventricular Function, Early Age of Repair and Prematurity.Pediatric cardiology · 2026Article
- Organ-level radiation dose estimations from cardiac catheterizations in neonates with tetralogy of Fallot.Radiation physics and chemistry (Oxford, England : 1993) · 2026Article
- Health-Related Quality of Life After Neonatal Treatment of Symptomatic Tetralogy of Fallot: Insights from the Congenital Cardiac Research Collaborative.Pediatric cardiology · 2025Article
- Timing and Mode of Death Following Treatment of Neonatal Symptomatic Tetralogy of Fallot.Journal of the American Heart Association · 2025Article
- Clinical Status and Reintervention in Neonates With Symptomatic Tetralogy of Fallot: A Landmark Analysis.JACC. Advances · 2025Article
- Repair of tetralogy of Fallot in neonates: a single-center case series.Translational pediatrics · 2025Article
- Is arterial ductal stent as effective as surgical shunt for palliation in staged repair of tetralogy of Fallot with pulmonary stenosis?Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Optimal Management of the Cyanotic Neonate With Tetralogy of Fallot-A Clinical Decision Analysis.Annals of thoracic surgery short reports · 2025Article
- Cardiovascular magnetic resonance in Tetralogy of Fallot-state of the art.Cardiovascular diagnosis and therapy · 2025Review
- Cumulative Radiation Exposure and Lifetime Cancer Risk in Patients With Tetralogy of Fallot Requiring Early Intervention.JACC. Advances · 2024Article
- Development and Validation of a Mortality Risk Score for Repaired Tetralogy of Fallot.Journal of the American Heart Association · 2024Article
- Article
- The Association of Gestational Age and Size with Management Strategies and Outcomes in Symptomatic Neonatal Tetralogy of Fallot.Pediatric cardiology · 2024Article
- Considerations in Timing of Surgical Repair in Tetralogy of Fallot.CJC pediatric and congenital heart disease · 2023Review
- Optimal Surgical Management of Tetralogy of Fallot.CJC pediatric and congenital heart disease · 2023Review
- Whole-exome sequencing revealed novel genetic alterations in patients with tetralogy of Fallot.Translational pediatrics · 2023Article
- Right Ventricular Strain in Patients With Ductal-Dependent Tetralogy of Fallot.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2023Article
- Palliation Strategy to Achieve Complete Repair in Symptomatic Neonates with Tetralogy of Fallot.Pediatric cardiology · 2022Article
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
33 authors at 11 institutions in 1 country.
Funding
Abstract
backgroundNeonates with tetralogy of Fallot and symptomatic cyanosis (sTOF) require early intervention.
objectivesThis study sought to perform a balanced multicenter comparison of staged repair (SR) (initial palliation [IP] and subsequent complete repair [CR]) versus primary repair (PR) treatment strategies.
methodsConsecutive neonates with sTOF who underwent IP or PR at ≤30 days of age from 2005 to 2017 were retrospectively reviewed from the Congenital Cardiac Research Collaborative. The primary outcome was death. Secondary outcomes included component (IP, CR, PR) and cumulative (SR): hospital and intensive care unit lengths of stay; durations of cardiopulmonary bypass, anesthesia, ventilation, and inotrope use; and complication and reintervention rates. Outcomes were compared using propensity score adjustment.
resultsThe cohort consisted of 342 patients who underwent SR (IP: surgical, n = 256; transcatheter, n = 86) and 230 patients who underwent PR. Pre-procedural ventilation, prematurity, DiGeorge syndrome, and pulmonary atresia were more common in the SR group (p ≤0.01). The observed risk of death was not different between the groups (10.2% vs 7.4%; p = 0.25) at median 4.3 years. After adjustment, the hazard of death remained similar between groups (hazard ratio: 0.82; 95% confidence interval: 0.49 to 1.38; p = 0.456), but it favored SR during early follow-up (<4 months; p = 0.041). Secondary outcomes favored the SR group in component analysis, whereas they largely favored PR in cumulative analysis. Reintervention risk was higher in the SR group (p = 0.002).
conclusionsIn this multicenter comparison of SR or PR for management of neonates with sTOF, adjusted for patient-related factors, early mortality and neonatal morbidity were lower in the SR group, but cumulative morbidity and reinterventions favored the PR group, findings suggesting potential benefits to each strategy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.