Evidence map›Paper›PMID 33632296›Full record

ArticleGut pathogens2021

Interplay between severities of COVID-19 and the gut microbiome: implications of bacterial co-infections?

Jyoti Chhibber-Goel, Sreehari Gopinathan, Amit Sharma

Open access · goldAbstract readLetter
In one paragraph

Article in Gut pathogens, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  6. Review
  7. COVID-19 host genetics and ABO blood group susceptibility.Cambridge prisms. Precision medicine · 2023
    Review
  8. The metaproteome of the gut microbiota in pediatric patients affected by COVID-19.Frontiers in cellular and infection microbiology · 2023
    Article
  9. Article
  10. Article
  11. Review
  12. Review
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  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jyoti Chhibber-GoelMolecular Medicine Group, International Center for Genetic Engineering and Biotechnology, New Delhi, India.
Sreehari GopinathanMolecular Medicine Group, International Center for Genetic Engineering and Biotechnology, New Delhi, India.
Amit SharmaMolecular Medicine Group, International Center for Genetic Engineering and Biotechnology, New Delhi, India. amitpsharma1968@gmail.com.ORCID http://orcid.org/0000-0002-3305-0034
International Centre for Genetic Engineering and Biotechnology · IN

Funding

Department of Biotechnology, Government of India BT/PR30603/BIC/101/1104/2018
6 · The paper itself

Abstract

COVID-19 is an acute respiratory distress syndrome and is often accompanied by gastrointestinal symptoms. The SARS-CoV-2 has been traced not only in nasopharyngeal and mid-nasal swabs but also in stool and rectal swabs of COVID-19 patients. The gut microbiota is important for an effective immune response as it ensures that unfavorable immune reactions in lungs and other vital organs are regulated. The human gut-lung microbiota interplay provides a framework for therapies in the treatment and management of several pulmonary diseases and infections. Here, we have collated data from COVID-19 studies, which suggest that bacterial co-infections as well as the gut-lung cross talk may be important players in COVID-19 disease prognosis. Our analyses suggests a role of gut microbiome in pathogen infections as well as in an array of excessive immune reactions during and post COVID-19 infection recovery period.

Indexed as

Angiotensin-converting enzyme 2Gut-lung axisGut-microbiomeOpportunistic pathogensProbioticsSARS-CoV-2

Identifiers

PMID33632296
PMCPMC7906082
OpenAlexW3133306514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.