Evidence map›Paper›PMID 33632233›Full record

ArticleMalaria journal2021

Xylopic acid-amodiaquine and xylopic acid-artesunate combinations are effective in managing malaria in Plasmodium berghei-infected mice.

Silas Acheampong Osei, Robert Peter Biney, Ernest Obese, Mary Atta-Panyi Agbenyeku, Isaac Yaw Attah, Elvis Ofori Ameyaw, Johnson Nyarko Boampong

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Malaria journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in pharmacology · 2023
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Silas Acheampong OseiDepartment of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
Robert Peter BineySchool of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Cape Coast, Ghana.
Ernest ObeseSchool of Pharmacy and Pharmaceutical Sciences, University of Cape Coast, Cape Coast, Ghana.
Mary Atta-Panyi AgbenyekuDepartment of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
Isaac Yaw AttahDepartment of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
Elvis Ofori AmeyawDepartment of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. elvisameyaw@gmail.com.ORCID http://orcid.org/0000-0002-8317-9602
Johnson Nyarko BoampongDepartment of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana.
University of Cape Coast · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence of Plasmodium resistance to some of the current anti-malarial agents makes it imperative to search for newer and effective drugs to combat malaria. Therefore, this study evaluated whether the co-administrations of xylopic acid-amodiaquine and xylopic acid-artesunate combinations will produce a synergistic anti-malarial effect.

methodsAntiplasmodial effect of xylopic acid (XA: 3, 10, 30, 100, 150 mg kg

resultsED

conclusionXylopic acid co-administration with either artesunate or amodiaquine produces a synergistic anti-plasmodial effect in mice infected with P. berghei.

Indexed as

AmodiaquineAnimalsAntimalarialsArtesunateDiterpenes, KauraneDose-Response Relationship, DrugDrug CombinationsFemaleMalariaMiceMice, Inbred ICRPlasmodium bergheiAmodiaquineAntimalarialsArtesunateDiterpenes, KauraneDrug Combinationsxylopic acidAmodiaquineAntimalarial drugsArtesunateCombination therapiesIsobolographic analysisPlasmodium bergheiSynergismXylopic acid

Identifiers

PMID33632233
PMCPMC7908739
OpenAlexW3132500468

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.