ArticleBMC pediatrics2021
Clinical signs associated with earlier diagnosis of children with autism Spectrum disorder.
Article in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Overall prognosis of preschool autism spectrum disorder diagnoses.The Cochrane database of systematic reviews · 2022Pooled it
- Computerized Adaptive Tests for Rapid and Accurate Assessment of Autism.JAMA network open · 2026Article
- Child Autism Spectrum Disorder Following Maternal Abuse and Trauma History.Journal of autism and developmental disorders · 2026Article
- Clinical Features of Children at Risk of Profound Autism.Journal of autism and developmental disorders · 2025Article
- What Happens After Autism Screening-Factors That Predict Evaluation Attendance.Journal of autism and developmental disorders · 2025Article
- Clinical determinants of psychiatric care in genetic neurodevelopmental disorders: a cross-sectional analysis.Journal of neurodevelopmental disorders · 2025Article
- Enlarged perivascular spaces under the dorso-lateral prefrontal cortex and severity of autism.Scientific reports · 2025Observational
- Article
- Clinical and sociodemographic factors related to the timing of autism diagnosis in an Italian cohort of children.Frontiers in psychiatry · 2025Article
- HERVs Endophenotype in Autism Spectrum Disorder: Human Endogenous Retroviruses, Specific Immunoreactivity, and Disease Association in Different Family Members.Microorganisms · 2024Review
- The association between prenatal psychosocial factors and autism spectrum disorder in offspring at 3 years: a prospective cohort study.Social psychiatry and psychiatric epidemiology · 2024Article
- Predictors of age at diagnosis in autism spectrum disorders: the use of multiple regression analyses and a classification tree on a clinical sample.European child & adolescent psychiatry · 2024Article
- The Interplay of Astrocytes and Neurons in Autism Spectrum Disorder.Advances in neurobiology · 2024Review
- 'If I don't Do It, I'm Out of Rhythm and I Can't Focus As Well': Positive and Negative Adult Interpretations of Therapies Aimed at 'Fixing' Their Restricted and Repetitive Behaviours in Childhood.Journal of autism and developmental disorders · 2023Article
- Parent-reported atypical development in the first year of life and age of autism diagnosis.Journal of autism and developmental disorders · 2023Article
- Autistic clinical profiles, age at first concern, and diagnosis among children with autism spectrum disorder.Frontiers in psychiatry · 2023Article
- Developmental and family environment predictors of diagnostic decision-making in children with autism spectrum disorder and comorbid disorders.Health psychology report · 2022Article
- Gender Differences in Misdiagnosis and Delayed Diagnosis among Adults with Autism Spectrum Disorder with No Language or Intellectual Disability.Brain sciences · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe objective of this study is to gain new insights into the relationship between clinical signs and age at diagnosis.
methodWe utilize a new, large, online survey of 1743 parents of children diagnosed with ASD, and use multiple statistical approaches. These include regression analysis, factor analysis, and machine learning (regression tree).
resultsWe find that clinical signs that most strongly predict early diagnosis are not necessarily specific to autism, but rather those that initiate the process that eventually leads to an ASD diagnosis. Given the high correlations between symptoms, only a few signs are found to be important in predicting early diagnosis. For several clinical signs we find that their presence and intensity are positively correlated with delayed diagnosis (e.g., tantrums and aggression). Even though our data are drawn from parents' retrospective accounts, we provide evidence that parental recall bias and/or hindsight bias did not play a significant role in shaping our results.
conclusionIn the subset of children without early deficits in communication, diagnosis is delayed, and this might be improved if more attention will be given to clinical signs that are not necessarily considered as ASD symptoms. Our findings also suggest that careful attention should be paid to children showing excessive tantrums or aggression, as these behaviors may interfere with an early ASD diagnoses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.