ArticleBMC musculoskeletal disorders2021
Association of osteoporosis and varus inclination of the tibial plateau in postmenopausal women with advanced osteoarthritis of the knee.
Article in BMC musculoskeletal disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Joint Reaction Forces Decrease Following Total Knee Arthroplasty up to 12-Months Post-Surgery.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Kinematic alignment yields a reduced knee adduction moment and better range of motion compared to mechanical alignment: biomechanical considerations of a staged, bilateral total knee arthroplasty case.BMC musculoskeletal disorders · 2026Article
- More severe microdamage and micromechanical alterations: altered subchondral bone remodeling in varus knee osteoarthritis with osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Deep‑learning based osteoporosis classification in knee X‑rays using transfer‑learning approach.Scientific reports · 2025Article
- Prediction of joint deformity after MIPPO with double reverse traction repositor based on Hounsfield units derived from CT scans.Journal of orthopaedic surgery and research · 2025Article
- Coronal plane alignment changes do not affect outcome for total knee implant design with 3 degree varus joint line.Journal of orthopaedic surgery and research · 2025Article
- A new superfluity deep learning model for detecting knee osteoporosis and osteopenia in X-ray images.Scientific reports · 2024Article
- Knee osteoarthritis: A review of animal models and intervention of traditional Chinese medicine.Animal models and experimental medicine · 2024Review
- The posterior tibial slope affects the measurement reliability regarding the radiographic parameter of the knee.BMC musculoskeletal disorders · 2024Article
- Comparison of both lower leg bone mineral density in single limb knee osteoarthritis patients.Archives of orthopaedic and trauma surgery · 2023Article
- Osteoporosis diagnosis in knee X-rays by transfer learning based on convolution neural network.Multimedia tools and applications · 2023Article
- Is Osteoarthritis Always Associated with Low Bone Mineral Density in Elderly Patients?Medicina (Kaunas, Lithuania) · 2022Article
- The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis.International journal of molecular sciences · 2021Review
- Raloxifene Ameliorates Glucosamine-Induced Insulin Resistance in Ovariectomized Rats.Biomedicines · 2021Article
- Osteoporosis is associated with varus deformity in postmenopausal women with knee osteoarthritis: a cross-sectional study.BMC musculoskeletal disorders · 2021Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough varus inclination of the tibial plateau has increasingly been recognized as a major risk factor in the progression of Osteoarthritis of the knee (OA knee), little attention has been placed on the development of the varus inclination of the tibial plateau. Osteoporosis is a disease characterized by low bone mass and may increase the risk of a stress fracture in the proximal tibia. To date, risk factors for varus inclination of the tibial plateau are rarely reported. In this study, we investigated Bone Mineral Density (BMD) as a risk factor of varus inclination of the tibial plateau in postmenopausal women with advanced OA knee.
methodsA total of 90 postmenopausal women with varus OA knee who had received a total knee arthroplasty in our department between January 2016 and December 2019 were reviewed. Certain factors may correlate to inclination of the tibial plateau (Medial Tibial Plateau Angle, MTPA), including age, operation side, Kellgren-Lawrence grade of OA knee, BMD, Body Mass Index (BMI), Lateral Distal Femur Angle (LDFA), lower extremity alignment (Hip-Knee-Ankle angle, HKAA), and history of both spinal compression fracture and hip fracture were collected and analyzed.
resultsOsteoporosis, lower extremity varus malalignment and age were significantly associated with varus inclination of the tibial plateau (MTPA) (P = 0.15, 0.013 and 0.033 respectively). For patients with a lower extremity varus malalignment (HKAA < 175°), osteoporosis (T-score ≤ -2.5) was significantly associated with inclination of the tibial plateau. For patients with a normal lower extremity alignment (HKAA ≥ 175°), no significant association was found between osteoporosis (T-score ≤ -2.5) and varus inclination of the tibial plateau.
conclusionsOsteoporosis, lower extremity varus malalignment and age are major risk factors for inclination of the tibial plateau in postmenopausal women with OA knee. More attention needs to be given to the progression of varus OA knee in postmenopausal women who simultaneously has osteoporosis and lower extremity varus malalignment.
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