ArticleTurkish journal of pharmaceutical sciences2021
A Synbiotic Mixture Ameliorates Depressive Behavior Induced by Dexamethasone or Water Avoidance Stress in a Mouse Model.
Article in Turkish journal of pharmaceutical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 12 citations in OpenAlex.
- Comparable organs weights and histopathological changes after administration of dexamethasone during pregnancy in rats.Open veterinary journal · 2026Article
- A Gut Microbial Metabolite Alleviates Stress-Induced Neurobehavioral Dysfunction in an Alzheimer's Disease Model.Molecular neurobiology · 2025Article
- The brown algaResearch in pharmaceutical sciences · 2025Article
- Nutritional Strategies in Major Depression Disorder: From Ketogenic Diet to Modulation of the Microbiota-Gut-Brain Axis.Molecular neurobiology · 2025Review
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectivesDisruption of the hypothalamic-pituitary-adrenal axis by stress and glucocorticoid drugs is a major cause of depression. The benefits of probiotics may extend to systems beyond the gastrointestinal tract, i.e., the central nervous system. Therefore, the effect of a synbiotic (probiotic + prebiotic) mixture on dexamethasone (Dex) and stress-induced depression was investigated. MATERIALS AND
methodsMale albino mice were used, the forced swimming test (FST) measured despair, and the sucrose preference test measured anhedonia. The synbiotic regimen (12.5x106 CFU) was supplemented in drinking water for 7 days. Dex was administered subcutaneously either in a single dose on the test day or for 7 days. Water avoidance stress (WAS) was induced for 1 hour each day for 4 days.
resultsDrinking the synbiotic reduced immobility time during the FST (54±7 sec vs. 111±6 sec in the control water group, p<0.001). Dex injection significantly increased the immobility time (single dose: 166±6 sec and 7 days: 174±9 sec) compared with the control groups, while adding the synbiotic to their drinking water reduced it (single dose: 81±6.6 sec, and 7 days: 84±14 sec), indicating that the synbiotic reversed Dex-induced depression. WAS increased the immobility time (148±11 sec vs. sham 99±6 sec, p<0.001) in the FST test. When the synbiotic treatment was added following WAS, the immobility time decreased (81±6.5 sec). The synbiotic groups also had a higher sucrose preference percentage.
conclusionThe synbiotic mixture prevented the effects of WAS, acute or sub-acute Dex-induced depression in mice. Therefore, probiotics might be useful and safe supplements to prevent depression related to stress or glucocorticoid therapies, a phenomenon that deserves further evaluation.
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