ArticlePlant physiology2021
Long chain acyl CoA synthetase 4 catalyzes the first step in peroxisomal indole-3-butyric acid to IAA conversion.
Article in Plant physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 37 citations in OpenAlex.
- Metabolism meets transport: a new perspective on auxin homeostasis at subcellular level.Planta · 2026Review
- Single-cell and spatial transcriptomics in Phragmites australis reveal the association of B chromosomes with plant invasiveness.Genome biology · 2026Article
- Genome-wide association study identifies key loci and candidate genes for seed vigor in upland cotton (Frontiers in plant science · 2026Article
- Auxin Biosynthesis, Transport, Signaling, and Its Roles in Plant Leaf Morphogenesis.Plants (Basel, Switzerland) · 2025Review
- Study on the cutting technology of chayote (Sechium edule) and the physiological mechanism of rooting regulation by exogenous hormones.BMC plant biology · 2025Article
- Species- and organ-specific contribution of peroxisomal cinnamate:CoA ligases to benzoic and salicylic acid biosynthesis.The Plant cell · 2024Article
- Multi-Omics Analysis of a Chromosome Segment Substitution Line Reveals a New Regulation Network for Soybean Seed Storage Profile.International journal of molecular sciences · 2024Article
- An auxin research odyssey: 1989-2023.The Plant cell · 2024Review
- Elucidation of the Mechanism of Rapid Growth Recovery in Rice Seedlings after Exposure to Low-Temperature Low-Light Stress: Analysis of Rice Root Transcriptome, Metabolome, and Physiology.International journal of molecular sciences · 2023Article
- Molecular Mapping of Putative Genomic Regions Controlling Fruit and Seed Morphology of Watermelon.International journal of molecular sciences · 2023Article
- WGCNA and transcriptome profiling reveal hub genes for key development stage seed size/oil content between wild and cultivated soybean.BMC genomics · 2023Article
- Expression of Physaria longchain acyl-CoA synthetases and hydroxy fatty acid accumulation in transgenic Arabidopsis.Journal of plant physiology · 2022Article
- Effects of Auxin (Indole-3-butyric Acid) on Adventitious Root Formation in Peach-BasedPlants (Basel, Switzerland) · 2022Article
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2 authors at 1 institution in 1 country.
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Abstract
Indole-3-butyric acid (IBA) is an endogenous storage auxin important for maintaining appropriate indole-3-acetic acid (IAA) levels, thereby influencingprimary root elongation and lateral root development. IBA is metabolized into free IAA in peroxisomes in a multistep process similar to fatty acid β-oxidation. We identified LONG CHAIN ACYL-COA SYNTHETASE 4 (LACS4) in a screen for enhanced IBA resistance in primary root elongation in Arabidopsis thaliana. LACSs activate substrates by catalyzing the addition of CoA, the necessary first step for fatty acids to participate in β-oxidation or other metabolic pathways. Here, we describe the novel role of LACS4 in hormone metabolism and postulate that LACS4 catalyzes the addition of CoA onto IBA, the first step in its β-oxidation. lacs4 is resistant to the effects of IBA in primary root elongation and dark-grown hypocotyl elongation, and has reduced lateral root density. lacs6 also is resistant to IBA, although both lacs4 and lacs6 remain sensitive to IAA in primary root elongation, demonstrating that auxin responses are intact. LACS4 has in vitro enzymatic activity on IBA, but not IAA or IAA conjugates, and disruption of LACS4 activity reduces the amount of IBA-derived IAA in planta. We conclude that, in addition to activity on fatty acids, LACS4 and LACS6 also catalyze the addition of CoA onto IBA, the first step in IBA metabolism and a necessary step in generating IBA-derived IAA.
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