Evidence map›Paper›PMID 33631548›Full record

ArticleDrug and alcohol dependence2021

Within- and between-person associations with drug use disorder among adolescents and emerging adults presenting to an urban emergency department.

Jason E Goldstick, Vivian H Lyons, Matthew G Myers, Maureen A Walton, Justin E Heinze, Rebecca M Cunningham

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jason E GoldstickDepartment of Emergency Medicine, University of Michigan, E Medical Center Drive, Ann Arbor, MI, 48109, United States; Injury Prevention Center, University of Michigan, 2800 Plymouth Road, Suite B10-G080, Ann Arbor, MI, 48109-2800, United States; Department of Health Behavior and Health Education, University of Michigan School of Public Health, 109 South Observatory Street, Ann Arbor, MI, 48109-2019, United States. Electronic address: jasoneg@umich.edu.
Vivian H LyonsHarborview Injury Prevention and Research Center, University of Washington, Gerberding Hall G80 Box 351202, Seattle, WA, 98195, United States.
Matthew G MyersDepartment of Emergency Medicine, University of Michigan, E Medical Center Drive, Ann Arbor, MI, 48109, United States; Injury Prevention Center, University of Michigan, 2800 Plymouth Road, Suite B10-G080, Ann Arbor, MI, 48109-2800, United States.
Maureen A WaltonInjury Prevention Center, University of Michigan, 2800 Plymouth Road, Suite B10-G080, Ann Arbor, MI, 48109-2800, United States; Department of Psychiatry, University of Michigan School of Medicine, 4250 Plymouth Road, Ann Arbor, MI, 48109, United States.
Justin E HeinzeInjury Prevention Center, University of Michigan, 2800 Plymouth Road, Suite B10-G080, Ann Arbor, MI, 48109-2800, United States; Department of Health Behavior and Health Education, University of Michigan School of Public Health, 109 South Observatory Street, Ann Arbor, MI, 48109-2019, United States; Youth Violence Prevention Center, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, United States.
Rebecca M CunninghamDepartment of Emergency Medicine, University of Michigan, E Medical Center Drive, Ann Arbor, MI, 48109, United States; Injury Prevention Center, University of Michigan, 2800 Plymouth Road, Suite B10-G080, Ann Arbor, MI, 48109-2800, United States; Department of Health Behavior and Health Education, University of Michigan School of Public Health, 109 South Observatory Street, Ann Arbor, MI, 48109-2019, United States; Youth Violence Prevention Center, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109, United States; Hurley Medical Center, Department of Emergency Medicine, 1 Hurley Plaza, Flint, MI, 48503, United States.
University of Michigan · USUniversity of Washington · US

Funding

Substance Use Among Violently Injured Youth in an Urban ER: Services and OutcomeR01DA024646 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CUNNINGHAM, REBECCA M. · 2009 to 2013
$2.9M
An innovative methodological approach to analyzing alcohol use transitions in the context of prescription drug misuse and other health behaviorsR03AA025449 · NIAAA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GOLDSTICK, JASON ELLIOTT · 2017 to 2018
$156k
NCIPC CDC HHS U01 CE002698NIAAA NIH HHS R03 AA025449NIDA NIH HHS R01 DA024646
6 · The paper itself

Abstract

backgroundThe distinction between within- and between-person associations with drug use disorder (DUD) has implications for intervention targets and content. We used longitudinal data from youth entering an urban emergency department (ED) to identify factors related to changes in DUD diagnosis, with particular emphasis on alcohol use.

methodsResearch staff recruited youth age 14-24 (n = 599) reporting any past six-month drug use from a Level-1 ED; participants were assessed at baseline and four biannual follow-ups. Participants self-reported validated measurements of peer/parental behaviors, violence/crime exposure, drug use self-efficacy, and alcohol use. Research staff performed diagnostic interviews for DUD with nine substances, post-traumatic stress disorder (PTSD), and major depressive disorder (MDD). We used repeated measures logistic regression models with person-level covariate means, and person-mean-centered covariates, as separate variables, to separate within- and between-person covariate effects.

resultsAmong 2,630 assessments, 1,128 (42.9 %) were DUD diagnoses; 21.7 % were co-diagnoses with multiple drugs. Positive (aOR = 0.81, 95 %CI:[0.70, 0.94]) and negative (aOR = 1.73, 95 %CI:[1.45, 2.07]) peer behaviors related to DUD, primarily through between-person effects. Parental support (aOR = 0.92, 95 %CI:[0.83, 0.99]), community violence/crime (aOR = 1.28, 95 %CI:[1.14, 1.44]), PTSD/MDD diagnosis (aOR = 1.36, 95 %CI:[1.04, 1.79]), and alcohol use quantity (aOR = 1.06, 95 %CI:[1.02, 1.11]) were associated with DUD, showing primarily within-person effects. Other factors, such as interpersonal violence involvement (aOR = 1.47, 95 %CI:[1.21, 1.78]), showed both within- and between-person effects.

conclusionsDUD is prevalent in this population, and within-person changes in DUD are predictable. Within-person effects suggest the importance of addressing escalating alcohol use, enhancing parental support, crime/violence exposure, and other mental health diagnoses as part of DUD intervention.

Indexed as

Interpersonal RelationsPeer GroupAdolescentAlcohol DrinkingEmergency Service, HospitalExposure to ViolenceFemaleHospitals, UrbanHumansLongitudinal StudiesMajor Depressive DisorderMaleOdds RatioParent-Child RelationsPrevalenceSelf EfficacyAlcoholDrug use disorderEmergency departmentLongitudinalYouth

Identifiers

PMID33631548
PMCPMC8026687
OpenAlexW3130290999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.