ArticleEpilepsy & behavior : E&B2021
Impact of COVID-19 on quality of life in people with epilepsy, and a multinational comparison of clinical and psychological impacts.
Article in Epilepsy & behavior : E&B, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Considering temporality in causal relationship between seizure worsening and psychological stress in patients with epilepsy during the COVID-19 pandemic: A systematic review.Epilepsy & behavior : E&B · 2021Pooled it
- Comparative trends in idiopathic epilepsy burden in China and worldwide based on Global Burden of Disease Study 2021.Epilepsy & behavior reports · 2026Article
- Global, regional and national burdens of epilepsy in the adolescents and young adults from 1990 to 2021 and its predictions.BMC neurology · 2025Article
- Anxiety and depression in people with epilepsy during and one year after the COVID-19 pandemic.Epilepsia open · 2025Observational
- Neuroglia and brain energy metabolism.Handbook of clinical neurology · 2025Review
- Influence of Clinical Factors on the Quality of Life in Romanian People with Epilepsy-A Follow-Up Study in Real-Life Clinical Practice.Journal of personalized medicine · 2023Article
- Post-9/11 veterans perceptions of the pandemic: Areas of greatest impact on health and well-being.PEC innovation · 2022Article
- Seizure control during the COVID-19 pandemic: Correlating Responsive Neurostimulation System data with patient reports.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- The metabolic basis of epilepsy.Nature reviews. Neurology · 2022Review
- Impact of COVID-19 pandemic on epilepsy care in Japan: A national-level multicenter retrospective cohort study.Epilepsia open · 2022Article
- A longitudinal seizure outcome following the COVID-19 pandemic in 2020 and 2021: Transient exacerbation or sustainable mitigation.Journal of the neurological sciences · 2022Article
- The impact of one-year COVID-19 containment measures in patients with mesial temporal lobe epilepsy: A longitudinal survey-based study.Epilepsy & behavior : E&B · 2022Article
- Psychological impact of the COVID-19 pandemic for patients with epilepsy: A systematic review and meta-analysis.Epilepsy & behavior : E&B · 2021Review
- Influence of COVID-19 pandemic on quality of life in patients with epilepsy - Follow-up study.Epilepsy & behavior : E&B · 2021Article
- The Influence of Telemedicine and Compassionate Care on the Quality of Life and Mental Health of Patients with Epilepsy in Northeastern China During the COVID-19 Crisis.Journal of multidisciplinary healthcare · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to determine the relationship among the clinical, logistic, and psychological impacts of COVID-19 on people with epilepsy (PWE), and the impact of COVID-19 on the quality of life.
methodThis is a cross-sectional anonymized web-based study on PWE, using an online questionnaire to assess the clinical, logistic, and psychological impacts of COVID-19, including Hospital Anxiety Depression Scale (HADS) and Quality of Life in Epilepsy Inventory (QOLIE-31).
result461 patients were recruited, with a mean age of 39.21 ± 15.88 years, majority female (50.1%), with focal epilepsy (54.0%), and experienced seizures at least once yearly (62.5%). There were 13.0% experienced seizure worsening during COVID-19 period, which were associated with baseline seizures frequency ≥ 1 per month (32.0% vs. 6.2%, p < 0.001), worries of seizure worsening (18.0% vs. 10.9%, p < 0.001), difficulty to go emergency unit (24.4% vs. 10.4%, p < 0.001), AEDs ran out of stock (23.2% vs. 11.6%, p < 0.05), self-adjustment of AED dosages (26.4% vs. 11.3%, p < 0.001), inadequate sleep (22.4% vs. 9.2%, p < 0.001), and stress (23.4% vs.10.1%, p < 0.01). Participants experiencing seizure worsening reported greater anxiety (8.10 ± 5.011 vs. 4.84 ± 3.989, p < 0.001) and depression (6.05 ± 3.868 vs. 3.86 ± 3.589, p < 0.001). Logistic regression showed baseline seizures frequency >1 per month (OR, 14.10) followed by anxiety (OR, 3.90), inadequate sleep (OR, 0.37), and treated in UMMC (OR, 0.31) as the predictors for seizure worsening during COVID-19 period. Poorer total QOLIE-31 score was noted in those with seizure worsening (48.01 ± 13.040 vs. 62.15 ± 15.222, p < 0.001). Stepwise regression highlighted depression as the main negative predictor for quality of life (β = -0.372, p < 0.001), followed by anxiety (β = -0.345, p < 0.001).
conclusionA significant number of PWE experienced seizure worsening during COVID-19 period, which was related to the clinical, logistic, and psychological factors. Quality of life was affected by the seizure worsening and the psychological stress.
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Registered trials
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