Evidence map›Paper›PMID 33631394›Full record

ReviewCurrent opinion in chemical biology2021

Supramolecular metal-based nanoparticles for drug delivery and cancer therapy.

Xiaomin Jiang, Chunbai He, Wenbin Lin

Abstract readReview
In one paragraph

Review in Current opinion in chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Supramolecular platinum complexes for cancer therapy.Current opinion in chemical biology · 2023
    Review
  7. Review
  8. Review
  9. Perspectives for the Use of Fucoidans in Clinical Oncology.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. pHEMA: An Overview for Biomedical Applications.International journal of molecular sciences · 2021
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaomin JiangDepartment of Chemistry, The University of Chicago, 929 E 57th St, Chicago, IL 60637, USA.
Chunbai HeDepartment of Chemistry, The University of Chicago, 929 E 57th St, Chicago, IL 60637, USA.
Wenbin LinDepartment of Chemistry, The University of Chicago, 929 E 57th St, Chicago, IL 60637, USA; Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago, 5758, S Maryland Ave, Chicago, IL, 60637, USA. Electronic address: wenbinlin@uchicago.edu.

Funding

Nanoscale Coordination Polymers Co-deliver Chemotherapeutics and siRNAs for Efficacious Treatment of Resistant Ovarian CancerR01CA216436 · NCI · UNIVERSITY OF CHICAGO · PI LIN, WENBIN · 2018 to 2022
$2.1M
Targeted Nanomedicines with Synergistic Chemotherapeutics to Enhance Immunotherapy of Metastatic Colorectal CancerR01CA223184 · NCI · UNIVERSITY OF CHICAGO · PI LIN, WENBIN · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA216436NCI NIH HHS R01 CA223184
6 · The paper itself

Abstract

Although conventional cancer therapies such as chemotherapy and radiotherapy prevail in clinic, they tend to have narrow therapeutic windows. Many chemotherapies have unfavorable pharmacokinetics while radiotherapy incurs radiotoxicity to normal tissues surrounding tumors. The chemical tunability of supramolecular metal-based nanoparticles (SMNPs) enables the incorporation of various therapeutics, including hydrophilic and hydrophobic chemotherapeutic drugs, photosensitizers, radiosensitizers, and biological therapeutics for more effective delivery to tumors. In this mini-review, we highlight recent advances in SMNPs, namely nanoscale coordination polymers and nanoscale metal-organic frameworks, for drug delivery and cancer therapy. We particularly focus on innovative uses of metal clusters, ligands, pores, and surface modifications to load various therapeutics into SMNPs and critical evaluations of the anticancer efficacies of SMNPs.

Indexed as

Antineoplastic AgentsHydrophobic and Hydrophilic InteractionsMetal NanoparticlesOxidation-ReductionPolymersAntineoplastic AgentsPolymersCancer therapyDrug deliverySupramolecular metal-based nanoparticle

Identifiers

PMID33631394
PMCPMC8219202

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.