ArticleAnnals of epidemiology2021
Symptom clusters predict risk of metabolic-syndrome and diabetes in midlife: the Study of Women's Health Across the Nation.
Article in Annals of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The trial behind it
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Who cites it
9 citing papers in PubMed.
- Neurokinin Antagonists to Treat Vasomotor Symptoms-Possible Implications for Long-Term Health and Disease.Journal of clinical medicine · 2025Article
- Understanding the menopause journey.Climacteric : the journal of the International Menopause Society · 2025Review
- Menopausal Hormone Therapy in Women with Type 2 Diabetes Mellitus: An Updated Review.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Review
- Reproductive risk factors across the female lifecourse and later metabolic health.Cell metabolism · 2024Review
- The interplay between diabetes mellitus and menopause: clinical implications.Nature reviews. Endocrinology · 2022Review
- Reliable Information from Health Professionals Encourages Urban Japanese Mothers' Continued Participation in Health Checkups.Healthcare (Basel, Switzerland) · 2022Article
- Disparities in Reproductive Aging and Midlife Health between Black and White women: The Study of Women's Health Across the Nation (SWAN).Women's midlife health · 2022Review
- Urinary concentrations of phenols and parabens and incident diabetes in midlife women: The Study of Women's Health Across the Nation.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Identification of high-risk symptom cluster burden group among midlife peri-menopausal and post-menopausal women with metabolic syndrome using latent class growth analysis.Women's health (London, England)Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeWomen's cardio-metabolic risk increases in midlife. Previous work relating menopause symptoms to diabetes/Metabolic Syndrome (MetS) does not consider the adverse impact of multiple concurrent physical and psychological symptoms in midlife.
methodsData are from 3097 participants in the Study of Women's Health Across the Nation, a cohort of midlife women followed for over 20 years. Baseline latent symptom classes (LSC) were derived from 58 questions assessing physical, psychological and menopausal symptoms. Six identified LSCs ranged from 1 (most symptoms present at high severity) to 6 (few symptoms present at low severity). Accelerated failure time models estimated time to onset of type 2 diabetes and MetS for each LSC.
resultsWomen with multiple high/moderate severity symptoms had an earlier onset of diabetes (13.2%, 14.1% and 20.8% earlier onset in LSCs 1, 2, 3, respectively) and MetS (15.5%, 13.0% and 19.7% earlier onset in LSCs 1, 2, 3, respectively) than women with few/low severity symptoms.
conclusionsHaving multiple concurrent moderate to high intensity physical and psychological symptoms in midlife are associated with early onset of diabetes and MetS. Monitoring and subsequent intervention on a broad range of symptoms in midlife may significantly mitigate cardio-metabolic risk during this critical life stage.
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