ArticleBrain, behavior, and immunity2021
Associations between peripheral inflammation and resting state functional connectivity in adolescents.
Article in Brain, behavior, and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- A comprehensive systematic review of fMRI studies on brain connectivity in healthy children and adolescents: Current insights and future directions.Developmental cognitive neuroscience · 2024Pooled it
- Effects of Dopaminergic Therapy with Levodopa (L-DOPA) on Fear and Anxiety-Related Circuits and Symptoms in Patients with Depression and Higher Inflammation.Brain, behavior, and immunity · 2026Trial
- Inflammation, fronto-amygdala connectivity, and negative affective reactivity to daily stress in adolescents.Brain, behavior, & immunity - health · 2026Article
- Neuroimmune programming of childhood trauma: comorbid mechanisms and developmental origins of depression and autoimmune diseases.Journal of neuroinflammation · 2026Review
- Socioeconomic Status Is Associated With Reward Processing, Interleukin 1β, Striatal Connectivity, and Antidepressant Outcomes in Individuals With Major Depressive Disorder: A CAN-BIND-1 Report.Biological psychiatry global open science · 2026Article
- The relationship between functional brain connectivity and neuroinflammatory processes-new insights into the pathomechanisms of ASD.Frontiers in neuroscience · 2026Review
- Cortisol, Anxiety, and TNFα Mediate the Relationship Between BMI and Executive Functions.Stress and health : journal of the International Society for the Investigation of Stress · 2025Article
- Value-based cognitive control moderates the relation of inflammation with depression in adolescents.Social cognitive and affective neuroscience · 2025Article
- Functional resting state connectivity is differentially associated with IL-6 and TNF-α in depression and in healthy controls.Scientific reports · 2025Article
- Peripheral contributions to resting state brain dynamics.Nature communications · 2024Article
- Socioeconomic Disadvantage Moderates the Association of Systemic Inflammation With Amygdala Volume in Adolescents Over a 2-Year Interval: An Exploratory Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Annual Research Review: Puberty and the development of anhedonia - considering childhood adversity and inflammation.Journal of child psychology and psychiatry, and allied disciplines · 2024Review
- Early life stress moderates the relation between systemic inflammation and neural activation to reward in adolescents both cross-sectionally and longitudinally.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders.Neuronal signaling · 2023Review
- Sleep quality mediates the relationship between systemic inflammation and neurocognitive performance.Brain, behavior, & immunity - health · 2023Article
- Inflammation-Related Functional and Structural Dysconnectivity as a Pathway to Psychopathology.Biological psychiatry · 2023Review
- Increased Inflammation and Treatment of Depression: From Resistance to Reuse, Repurposing, and Redesign.Advances in neurobiology · 2023Article
- Peripheral inflammation and neurocognitive impairment: correlations, underlying mechanisms, and therapeutic implications.Frontiers in aging neuroscience · 2023Review
- Sleep duration moderates the associations between immune markers and corticolimbic function during stress in adolescents.Neuropsychologia · 2022Article
- Early life stress, systemic inflammation, and neural correlates of implicit emotion regulation in adolescents.Brain, behavior, and immunity · 2022Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Relatively little is known about associations between peripheral inflammation and neural function in humans. Neuroimaging studies in adults have suggested that elevated peripheral inflammatory markers are associated with altered resting state functional connectivity (rsFC) in several brain networks associated with mood and cognition. Few studies have examined these associations in adolescents, yet scarce data from adolescents point to different networks than adult studies. The current study examined the associations between peripheral inflammation and rsFC in a community sample of adolescents (n = 70; age, 12-15 years; 32 female, 36 male, 2 nonbinary). After blood sampling, an fMRI scan was performed to assess rsFC. Assay for serum inflammatory markers, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP), was performed. Results indicated that higher TNF-α was associated with altered rsFC between the right amygdala and left striatum and between the right inferior frontal gyrus and left parietal cortex (p < 0.05 whole-brain corrected). Associations with IL-6 and CRP were not significant. In contrast with findings in adults, inflammation may have unique links with the connectivity of the developing adolescent brain. Results have implications for understanding how peripheral inflammation may influence connectivity during adolescence, when neural networks are undergoing major developmental changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.