ArticleAmerican journal of ophthalmology2021
Juxtapapillary Deep-Layer Microvasculature Dropout and Retinal Nerve Fiber Layer Thinning in Glaucoma.
Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Choroidal microvascular dropout and its relationship to progression in primary open-angle and pseudoexfoliation glaucoma.BMC ophthalmology · 2025Article
- Optic nerve head factors associated with initial central visual field defect in primary open-angle glaucoma.Scientific reports · 2024Article
- Clinical Significance of Recurrent Disc Hemorrhage and Choroidal Microvasculature Dropout on Optical Coherence Tomography Angiography in Glaucoma.Investigative ophthalmology & visual science · 2024Article
- Clinical characteristics of open-angle glaucoma progression with peripapillary microvasculature dropout in different locations.Eye (London, England) · 2024Article
- Relationship of Choroidal Microvasculature Dropout and Beta Zone Parapapillary Area With Visual Field Changes in Glaucoma.American journal of ophthalmology · 2024Observational
- Temporal Optic Disc Microvasculature Dropout in Glaucoma.Investigative ophthalmology & visual science · 2023Article
- Discrepancy between peripapillary retinal and choroidal microvasculature and the rate of localized retinal nerve fiber layer thinning in glaucoma.Scientific reports · 2023Observational
- Effects of Tafluprost on Ocular Blood Flow.Ophthalmology and therapy · 2022Review
- Rates of Choroidal Microvasculature Dropout and Retinal Nerve Fiber Layer Changes in Glaucoma.American journal of ophthalmology · 2022Article
- The characteristics of fundus microvascular alterations in the course of glaucoma: a narrative review.Annals of translational medicine · 2022Review
- Optic Disc Microvasculature Dropout in Glaucoma Detected by Swept-Source Optical Coherence Tomography Angiography.American journal of ophthalmology · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeWe sought to characterize juxtapapillary (JP) and non-JP microvasculature dropout in patients with primary open-angle glaucoma and to compare their rate of retinal nerve fiber layer (RNFL) thinning.
designRetrospective cohort study.
methodsA total of 141 eyes with primary open-angle glaucoma with ≥4 serial optical coherence tomography (OCT) images after initial OCT angiography for ≥2 years were included. Based on OCT angiography imaging, the 3 groups were matched by age and visual field mean deviation: JP group (parapapillary deep-layer microvasculature dropout in contact with the optic disc boundary, n = 47), non-JP group (dropout not reaching the optic disc boundary, n = 47), and no-dropout group (lacking the dropout, n = 47). The RNFL thinning rate was compared among the 3 groups.
resultsThe rate of RNFL thinning tended to be fastest in the JP group followed by the non-JP group and no-dropout group in all areas except the temporal and nasal sectors. Post hoc analysis revealed that the JP group had significantly faster RNFL thinning than did the no-dropout group in the global area and the inferotemporal and inferonasal sectors (P < .05). When subgroup analysis was performed for subjects in which the main sector of dropout was the inferotemporal sector, the JP group had significantly faster RNFL thinning than the other 2 groups in the corresponding inferotemporal sector (P < .001).
conclusionEyes with JP microvasculature dropout showed faster RNFL thinning than eyes without dropout. These findings suggest that deep-layer microvasculature dropout, especially in contact with the optic disc boundary, is associated with rapid glaucoma progression.
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Registered trials
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