ArticleImmunity2021
A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs.
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Article in Immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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67citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
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Who cites it
67 citing papers in PubMed, 91 citations in OpenAlex.
- Exposure route, not dose, is the primary driver of infection patterns for a respiratory virus.Science advances · 2026Article
- Harnessing mucosal immunity for protective vaccines.Nature reviews. Immunology · 2026Review
- Heterologous vaccination with a next-generation vaccinia virus and Ad26 induces Ebola-specific immunity in macaques.NPJ vaccines · 2026Article
- Exposure route drives SARS-CoV-2 infection patterns in non-human primates.bioRxiv : the preprint server for biology · 2026Article
- Humoral epitope dominance and immune imprinting by SARS-CoV-1 and SARS-CoV-2 vaccines.Immunology and cell biology · 2026Article
- Inflammation from mild COVID-19 results in persistent neurological and behavioral changes in rhesus macaques.Research square · 2025Article
- Monocyte-eosinophil signaling axis promotes vaccine-mediated protection against SARS-CoV-2.PLoS pathogens · 2025Article
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- Insect Cell-Based Quadrivalent Seasonal Influenza Virus-like Particles Vaccine Elicits Potent Immune Responses in Mice.Vaccines · 2024Article
- DNA vaccine prime and replicating vaccinia vaccine boost induce robust humoral and cellular immune responses against MERS-CoV in mice.Virologica Sinica · 2024Article
- Olfactory immunology: the missing piece in airway and CNS defence.Nature reviews. Immunology · 2024Review
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- Olfactory immune response to SARS-CoV-2.Cellular & molecular immunology · 2024Review
- MVA-based vaccine candidates encoding the native or prefusion-stabilized SARS-CoV-2 spike reveal differential immunogenicity in humans.NPJ vaccines · 2024Article
- High throughput analysis of B cell dynamics and neutralizing antibody development during immunization with a novel clade C HIV-1 envelope.PLoS pathogens · 2023Article
- C5aRNPJ vaccines · 2023Article
- Vaccinia E5 is a major inhibitor of the DNA sensor cGAS.Nature communications · 2023Article
- Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases.Signal transduction and targeted therapy · 2023Review
7 more citing papers are in PubMed but not listed here.
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Authors and funding
32 authors at 5 institutions in 1 country.
Nanda Kishore RouthuEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Narayanaiah CheedarlaEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Sailaja GangadharaEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Venkata Satish BollimpelliEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Arun K BoddapatiEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Ayalnesh ShiferawEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Sheikh Abdul RahmanEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Anusmita SahooEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Venkata Viswanadh EdaraEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.
Lilin LaiEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.
Katharine FloydEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.
Shelly WangEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Stephanie FischingerRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Caroline AtyeoRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Sally A ShinRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Sanjeev GumberDivision of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Shannon KirejczykDivision of Pathology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Joyce CohenDivision of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Sherrie M JeanDivision of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Jennifer S WoodDivision of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Fawn Connor-StroudDivision of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Rachelle L StammenDivision of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
Amit A UpadhyayEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Kathryn PellegriniEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
David MontefioriDepartment of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.
Pei-Yong ShiDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, TX, USA.
Vineet D MenacheryDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX, USA.
Galit AlterRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Thomas H VanderfordEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA.
Steven E BosingerEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pathology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA.
Mehul S SutharEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Pediatrics, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA.
Rama Rao AmaraEmory Vaccine Center, Division of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA; Department of Microbiology and Immunology, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA. Electronic address: ramara@emory.edu.
Emory University · USEmory Healthcare · USRagon Institute of MGH, MIT and Harvard · USThe University of Texas Medical Branch at Galveston · USDuke University · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MMVA Prime/Novel Trimeric Cyclically Permuted Envelope Protein Boost Vaccines for HIVR01AI148378 · NIAID · EMORY UNIVERSITY · PI AMARA, RAMA RAO · 2019 to 2022
$3.7MIllumina NovaSeq 6000 High Throughput DNA Sequencer for Emory UniversityS10OD026799 · OD · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD · 2019 to 2019
$985kNIAID NIH HHS HHSN272201400008CNIAID NIH HHS R01 AI148378NIH HHS P51 OD011132NIH HHS S10 OD026799
Abstract
A combination of vaccination approaches will likely be necessary to fully control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Here, we show that modified vaccinia Ankara (MVA) vectors expressing membrane-anchored pre-fusion stabilized spike (MVA/S) but not secreted S1 induced strong neutralizing antibody responses against SARS-CoV-2 in mice. In macaques, the MVA/S vaccination induced strong neutralizing antibodies and CD8
Indexed as
AnimalsAntibodies, NeutralizingAntibodies, ViralAntigens, ViralCOVID-19COVID-19 VaccinesDisease Models, AnimalGene ExpressionGene OrderGenetic VectorsImmunophenotypingLungMacacaMacrophages, AlveolarMiceSARS-CoV-2Antibodies, NeutralizingAntibodies, ViralAntigens, ViralCOVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Vaccines, DNACD8 T cellsCOVID-19Modified Vaccinia AnkaraNeutralizing antibodyProtectionRhesus macaquesSARS-CoV-2SpikeVaccine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.