ArticlePLoS genetics2021
Designing gene drives to limit spillover to non-target populations.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Identifying Transgenic Approaches to Mitigate Vector Transmission of Malaria by Anopheles gambiae.Cureus · 2026Review
- Mapping Gene Drive Dynamics onto Mendelian Models.bioRxiv : the preprint server for biology · 2026Article
- Predicting the invasiveness of threshold-dependent gene drives.bioRxiv : the preprint server for biology · 2025Article
- Is Gene Drive Research Losing Traction?The American journal of tropical medicine and hygiene · 2025Article
- Controlling the frequency dynamics of homing gene drives for intermediate outcomes.G3 (Bethesda, Md.) · 2025Article
- Integrated Pest Management: An Update on the Sustainability Approach to Crop Protection.ACS omega · 2024Review
- Gene drive designs for efficient and localisable population suppression using Y-linked editors.PLoS genetics · 2022Article
- Chemical Ecology and Olfaction in Short-Horned Grasshoppers (Orthoptera: Acrididae).Journal of chemical ecology · 2022Review
- Demographic feedbacks can hamper the spatial spread of a gene drive.Journal of mathematical biology · 2021Article
- Gene drive strategies of pest control in agricultural systems: Challenges and opportunities.Evolutionary applications · 2021Article
- Evading resistance to gene drives.Genetics · 2021Article
- Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes.Nature communications · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The prospect of utilizing CRISPR-based gene-drive technology for controlling populations has generated much excitement. However, the potential for spillovers of gene-drive alleles from the target population to non-target populations has raised concerns. Here, using mathematical models, we investigate the possibility of limiting spillovers to non-target populations by designing differential-targeting gene drives, in which the expected equilibrium gene-drive allele frequencies are high in the target population but low in the non-target population. We find that achieving differential targeting is possible with certain configurations of gene-drive parameters, but, in most cases, only under relatively low migration rates between populations. Under high migration, differential targeting is possible only in a narrow region of the parameter space. Because fixation of the gene drive in the non-target population could severely disrupt ecosystems, we outline possible ways to avoid this outcome. We apply our model to two potential applications of gene drives-field trials for malaria-vector gene drives and control of invasive species on islands. We discuss theoretical predictions of key requirements for differential targeting and their practical implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.