ArticleJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society2021
Peripapillary Hyper-reflective Ovoid Mass-like Structure (PHOMS): An Optical Coherence Tomography Marker of Axoplasmic Stasis in the Optic Nerve Head.
Article in Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 89 citations in OpenAlex.
- Optic disc morphology and myopia severity in eyes with peripapillary hyperreflective ovoid mass-like structures.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Optical coherence tomography measurement of retinal layers above the peripapillary hyperreflective ovoid mass-like structure in true papilloedema and pseudo-papilloedema.Eye (London, England) · 2026Article
- Automated segmentation and quantification of peripapillary hyperreflective ovoid mass-like structures using swept-source optical coherence tomography.BMC ophthalmology · 2026Article
- Peripapillary Hyperreflective Ovoid Mass-Like Structure as an Optic Disc Pseudo-Edema Case Report and Review.Case reports in ophthalmological medicine · 2026Article
- Peripapillary hyperreflective ovoid mass-like structure in arteritic versus nonarteritic anterior ischemic optic neuropathy.Frontiers in ophthalmology · 2026Article
- Retinal peripapillary nerve fiber and retinal ganglion cell layer thickening preceed atrophy in children and teenagers with optic disc drusen.Scientific reports · 2025Observational
- The Observation of Peripapillary Hyperreflective Ovoid Mass-Like Structures in Adolescents by Swept-Source Optical Coherence Tomography Angiography.Translational vision science & technology · 2025Article
- Identifying biomarkers for papilledema and pseudopapilledema.Scientific reports · 2025Article
- Peripapillary Hyperreflective Ovoid Mass-Like Structures: Prevalence and Associations in the Adult Population of the Beijing Eye Study.Investigative ophthalmology & visual science · 2025Article
- Clinical presentation and optical coherence tomography findings of intrapapillary hemorrhage with adjacent peripapillary subretinal hemorrhage.American journal of ophthalmology case reports · 2025Article
- Peripapillary choroidal vascularity of paediatric myopic eyes with peripapillary hyperreflective ovoid mass-like structures.Acta ophthalmologica · 2025Article
- Is the presence of peripapillary hyperreflective ovoid mass-like structures (PHOMS) in children related to the optic disc area, scleral canal diameter and refractive status?Eye (London, England) · 2025Article
- Distinguishing Papilledema from Pseudopapilledema in Children.Advances in ophthalmology and optometry · 2024Article
- Peripapillary hyperreflective ovoid mass-like structures with cystoid macular edema: a case report.BMC ophthalmology · 2024Article
- Features of Peripapillary Hyperreflective Ovoid Mass-Like Structures in Nonarteritic Anterior Ischemic Optic Neuropathy Patients and Normal Controls.Translational vision science & technology · 2024Article
- Peripapillary hyperreflective ovoid mass-like structures: multimodal imaging and associated diseases.Frontiers in neurology · 2024Review
- Application of novel non-invasive ophthalmic imaging to visualize peripapillary wrinkles, retinal folds and peripapillary hyperreflective ovoid mass-like structures associated with elevated intracranial pressure.Frontiers in neurology · 2024Article
- Optical Coherence Tomography in a Morning Glory Disc Anomaly with a Peripapillary Choroidal Neovascular Membrane.Neuro-ophthalmology (Aeolus Press) · 2024Article
- Case Report: Optic Disc Melanocytoma with PHOMS-Minimum Intensity Projection Image.International medical case reports journal · 2024Article
- Multimodal imaging of optic nerve head abnormalities in high myopia.Frontiers in neurology · 2024Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundWith the development and widespread adoption of spectral-domain optical coherence tomography (OCT), peripapillary hyper-reflective ovoid mass-like structures (PHOMS) have become a frequent OCT finding in neuro-ophthalmic practice. Although originally assumed to represent a form of buried optic disc drusen (ODD), PHOMS differ from ODD in many important ways. The histopathological underpinnings of PHOMS are now becoming more clearly understood. EVIDENCE ACQUISITION: Review of literature.
resultsPHOMS can be broadly classified as disk edema-associated PHOMS, ODD-associated PHOMS, or anomalous disk-associated PHOMS. PHOMS are seen in many conditions, including papilledema, nonarteritic anterior ischemic optic neuropathy, central retinal vein occlusion, acute demyelinating optic neuritis, ODD, and tilted disks (myopic obliquely inserted disks) and in many cases resolve along with the underlying condition. The histopathological study of these diverse entities reveals the common feature of a bulge of optic nerve fibers herniating centrifugally over Bruch membrane opening into the peripapillary space, correlating exactly with the location, shape, and space-occupying nature of PHOMS on OCT. Because of the radial symmetry of these herniating optic nerve fibers, PHOMS are best thought of as a complete or partial torus (i.e., donut) in 3 dimensions.
conclusionsPHOMS are a common but nonspecific OCT marker of axoplasmic stasis in the optic nerve head. They are not themselves ODD or ODD precursors, although they can be seen in association with ODD and a wide spectrum of other conditions. They do not exclude papilledema and often accompany it. The circumferential extent and characteristic 3D toroidal nature of a PHOMS are best appreciated by scrolling through consecutive OCT images.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.