Evidence map›Paper›PMID 33630671›Full record

ReviewSystems biology in reproductive medicine2021

Extracellular vesicle cargo of the male reproductive tract and the paternal preconception environment.

Ahmet Ayaz, Emily Houle, J Richard Pilsner

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Systems biology in reproductive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ahmet AyazDepartment of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
Emily HouleDepartment of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
J Richard PilsnerDepartment of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA.
University of Massachusetts Amherst · US

Funding

Paternal preconception phthalates and reproductive health - potential mediation through sperm DNA methylation.R01ES028298 · NIEHS · WAYNE STATE UNIVERSITY · PI PILSNER, J. RICHARD · 2018 to 2023
$2.7M
Male preconception phthalates and offspring embryo and sperm allele-specific methylome programming.R01ES028214 · NIEHS · WAYNE STATE UNIVERSITY · PI PILSNER, J. RICHARD · 2017 to 2021
$2.3M
Determining how preconception exposure to phthalates impacts sperm function, the epigenome fertility and reproductive outcomes in mice and menR01ES030942 · NIEHS · WAYNE STATE UNIVERSITY · PI PILSNER, J. RICHARD · 2019 to 2021
$1.5M
NIEHS NIH HHS R01 ES028214NIEHS NIH HHS R01 ES028298NIEHS NIH HHS R01 ES030942
6 · The paper itself

Abstract

The molecular composition of extracellular vesicles (EVs) is emerging as a novel biomarker in many areas of research including reproductive health. EVs transport biological molecules such as RNA and protein to facilitate cell-to-cell communication among cells of the male reproductive tract. Human and animal studies have shown that EVs present in seminal plasma or in the male reproductive tract contain important cargo that are important for successful reproductive outcomes. Small non-coding RNAs (sncRNA) have been at the forefront of this research, and as such, they have the potential to serve as novel biomarkers of male infertility diagnosis and reproductive success. This review provides an overview of EV biosynthesis and examines the molecular payloads of seminal plasma EVs on male infertility and reproductive success as well as future research that is warranted to examine how these molecular payloads may be modified by environmental factors.

Indexed as

Extracellular VesiclesInfertility, MaleAnimalsBiomarkersCell CommunicationHumansMaleReproductionSemenBiomarkersenvironmentexosomesExtracellular vesiclesmale reproductive healthpreconceptionseminal plasmasmall noncoding RNAsncRNA

Identifiers

PMID33630671
PMCPMC8272945
OpenAlexW3132278029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.