Evidence map›Paper›PMID 33630244›Full record

ArticleFood and environmental virology2021

Hepatitis E Virus (HEV) Spread and Genetic Diversity in Game Animals in Northern Italy.

Sara Arnaboldi, Francesco Righi, Valentina Carta, Silvia Bonardi, Enrico Pavoni, Alessandro Bianchi, Marina Nadia Losio, Virginia Filipello

Abstract read
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In one paragraph

Article in Food and environmental virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Genetic Heterogeneity of Hepatitis E Virus (HEV) in Wild Boars in Italy.Animals : an open access journal from MDPI · 2026
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  19. Hepatitis E virus detection in hunted wild boar (Italian journal of food safety · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sara ArnaboldiDepartment of Food Safety, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), via A. Bianchi 9, 25124, Brescia, Italy.ORCID 0000-0002-1666-7518
Francesco RighiDepartment of Food Safety, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), via A. Bianchi 9, 25124, Brescia, Italy.
Valentina CartaDepartment of Food Safety, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), via A. Bianchi 9, 25124, Brescia, Italy.
Silvia BonardiDepartment of Veterinary Science, Università degli Studi di Parma, 43100, Parma, Italy.ORCID 0000-0003-3079-9290
Enrico PavoniDepartment of Food Safety, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), via A. Bianchi 9, 25124, Brescia, Italy.ORCID 0000-0003-4367-0381
Alessandro BianchiLombardy Territorial Area Department, Istituto Zooprofilattico della Lombardia e dell'Emilia Romagna (IZSLER), 23100, Sondrio, Italy.
Marina Nadia LosioDepartment of Food Safety, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), via A. Bianchi 9, 25124, Brescia, Italy.ORCID 0000-0002-7434-6536
Virginia FilipelloDepartment of Food Safety, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna (IZSLER), via A. Bianchi 9, 25124, Brescia, Italy. virginia.filipello@izsler.it.ORCID 0000-0003-4569-5793

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis E virus (HEV) is the causative agent of hepatitis E, an emerging public health infection which has an increasing incidence across Europe. Because of the apparent lack of species barriers, HEV was characterized as a zoonotic agent. Swine are recognized as the main reservoir, but HEV is also found in wild animals such as ungulates, lagomorphs, and bats. Our work aimed at detecting the HEV presence in wild fauna in two hunting areas of Northern Italy (Parma and Sondrio areas) with different environmental and anthropic characteristics to investigate its possible role as reservoir. Liver samples were collected from wild boars, red deer, roe deer and chamois, and viral identification was carried out by One-Step RT Real-time PCR. Positive samples were genotyped, and phylogenetic analysis was performed. The virus was found only in the wild boar population, with different prevalence and subtypes in the two areas (14% HEV3a and 1.2% close to HEV3f in Parma and Sondrio, respectively). Wild ruminants seem otherwise to pose a marginal risk. Given the high pig farm density in the Parma area, and expansion of the wild boar population, continuous monitoring of the strains circulating in wildlife is crucial.

Indexed as

Genetic VariationAnimalsAnimals, WildDeerDisease ReservoirsHepatitis EHepatitis E virusItalyPhylogenyRupicapraSus scrofaViral ZoonosesFoodborne virusesGame meatHepatitis E virusWild ungulates

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.