Evidence map›Paper›PMID 33630216›Full record

ArticleDigestive diseases and sciences2021

Increased Use of Prophylactic Measures in Preventing Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis.

Christina J Sperna Weiland, Megan M L Engels, Alexander C Poen, Abha Bhalla, Niels G Venneman, Jeanin E van Hooft, Marco J Bruno, Robert C Verdonk, Paul Fockens, Joost P H Drenth and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Christina J Sperna WeilandDepartment of Gastroenterology and Hepatology, Radboudumc, Nijmegen, The Netherlands.ORCID 0000-0001-6124-6256
Megan M L EngelsDepartment of Research and Development, St. Antonius Ziekenhuis, Nieuwegein, The Netherlands.
Alexander C PoenDepartment of Gastroenterology and Hepatology, Isala Clinics, Zwolle, The Netherlands.
Abha BhallaDepartment of Gastroenterology and Hepatology, Hagaziekenhuis, The Hague, The Netherlands.
Niels G VennemanDepartment of Gastroenterology and Hepatology, Medisch Spectrum Twente, Enschede, The Netherlands.
Jeanin E van HooftDepartment of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, The Netherlands.
Marco J BrunoDepartment of Gastroenterology and Hepatology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Robert C VerdonkDepartment of Gastroenterology and Hepatology, St. Antonius Ziekenhuis, Nieuwegein, The Netherlands.
Paul FockensDepartment of Gastroenterology and Hepatology, Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Joost P H DrenthDepartment of Gastroenterology and Hepatology, Radboudumc, Nijmegen, The Netherlands.
Erwin J M van GeenenDepartment of Gastroenterology and Hepatology, Radboudumc, Nijmegen, The Netherlands. Erwin.vangeenen@radboudumc.nl.
Dutch Pancreatitis Study Group
Radboud University Nijmegen · NLSt. Antonius Ziekenhuis · NLAmsterdam University Medical Centers · NLErasmus University Rotterdam · NLHaga Hospital · NLIsala · NLLeiden University · NLMedisch Spectrum Twente · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNonsteroidal anti-inflammatory drugs (NSAIDs), pancreatic duct stenting, and intensive intravenous hydration have been proven to prevent post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Trial participation and guideline changes demanded an assessment of the clinical practice of post-ERCP pancreatitis prophylaxis.

aimsThe surveys aim to identify points of improvement to inform and educate ERCPists about current evidence-based practice.

methodsTwo anonymous surveys were conducted among Dutch gastroenterologists in 2013 (n = 408) and 2020 (n = 575) for longitudinal views and attitudes pertaining to post-ERCP pancreatitis prophylaxis and recognition of post-ERCP pancreatitis risk factors.

resultsIn 2013 and 2020, respectively, 121 and 109 ERCPists responded. In the 2013 survey, 98% of them utilized NSAID prophylaxis and 62% pancreatic duct stent prophylaxis in specific cases. In the 2020 survey, the use of NSAIDs (100%), pancreatic duct stents (78%), and intensive intravenous hydration (33%) increased among ERCPists. NSAID prophylaxis was the preferred prophylactic measure for all risk factors in the 2020 survey, except for ampullectomy, pancreatic duct contrast injection, and pancreatic duct cannulation, for which NSAID prophylaxis and pancreatic duct stent combined was equally favored or preferred.

conclusionRectal NSAIDs are the most applied post-ERCP pancreatitis prophylaxis in the Netherlands, followed by pancreatic duct stents and intensive intravenous hydration. Additionally, there is reason to believe that recent guideline updates and active research participation have led to increased prophylaxis implementation.

Indexed as

AdultAnti-Inflammatory Agents, Non-SteroidalCholangiopancreatography, Endoscopic RetrogradeFemaleGastroenterologistsGastroenterologyHumansMaleMiddle AgedPancreatitisPractice Guidelines as TopicStentsSurveys and QuestionnairesAnti-Inflammatory Agents, Non-SteroidalEndoscopic retrograde cholangiopancreatographyERCPGastroenterologistsInfusionsIntravenousNonsteroidal anti-inflammatory agentsPancreatic ductsPancreatitisRisk factorsRisk reduction behaviorSurveys and questionnaires

Identifiers

PMID33630216
PMCPMC8589790
OpenAlexW3133101953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.